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首页> 外文期刊>Journal of neurology >Epiretieal membrane: a treatable cause of visual disability in myotoeic dystrophy type 1
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Epiretieal membrane: a treatable cause of visual disability in myotoeic dystrophy type 1

机译：闭幕膜：肌营养不良型视觉残疾的可治疗原因1

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摘要

A wide range of ocular abnormalities have been documented to occur in patients with myotonic dystrophy type 1. The objectives of this study were to investigate the macular and optic nerve morphology using optical coherence tomography in patients with myotonic dystrophy type 1. A total of 30 myotonic dystrophy type 1 patients and 28 controls were recruited for participation. All participants underwent a thorough ophthalmologic examination, including spectral-domain optical coherence tomography of the macula and retinal nerve fibre layer. Images were reviewed by a retinal specialist ophthalmologist, masked to the diagnosis of the participants. Average macular thickness was significantly greater in the myotonic dystrophy group compared to controls [327.3 um vs. 308.5 um (p < 0.001)]. Macular thickness was significantly greater (p < 0.005) in five of the nine macular regions. The increase in macular thickness was due to the increased prevalence of epiretinal membranes in the myotonic dystrophy patient group (p = 0.0002): 48.2 % of myotonic dystrophy patient eyes had evidence of epiretinal membrane, compared with 12.5 % of control eyes. Examination revealed that 56.7 % of myotonic dystrophy patients had an epiretinal membrane in at least one eye. Visual acuity was reduced due to the presence of epiretinal membrane in six patient eyes and none of the control eyes. The presence of an epiretinal membrane was significantly correlated with increasing age in the patient group. We report an increased prevalence of epiretinal membrane in the myotonic dystrophy type 1 group. This may be a previously under-recognised form of visual impairment in this group. Epiretinal membranes can be treated surgically. We suggest that, in addition to a comprehensive clinical examination, optical coherence tomography examination is implemented as part of an ophthalmological assessment for the myotonic dystrophy type 1 patient with reduced visual acuity.
机译：已经记录了各种眼镜的肌营养不良症患者。本研究的目的是使用肌肌营养不良型患者使用光学相干断层扫描来研究黄斑和视神经形态1.总共30次肌肌营养不良1患者和28名对照被招募参与。所有参与者都经历了彻底的眼科检查，包括黄斑和视网膜神经纤维层的光谱结构域光学相干术。视网膜专业眼科医生审查了图像，掩盖了参与者的诊断。与对照相比，肌肌营养不良组平均黄斑厚度显着大幅度较大[327.3 um与308.5μm（p <0.001）]。在九个黄斑区域中，黄斑厚度明显较大（P <0.005）。黄斑厚度的增加是由于肌营养不良患者组中的表位膜的流行增加（p = 0.0002）：48.2％的肌营养不良患者眼睛有表现因子膜的证据，与12.5％的对照眼相比。检查显示，56.7％的肌营养不良患者在至少一只眼睛中具有齿膜膜膜。由于六名患者眼睛中的表位膜存在，视力降低了视力，并且没有控制眼睛。与患者组中的增长显着相关，表位膜显着相关。我们报告了在肌营养不良型1型组中表现出的表膜膜普及率增加。这可能是此组先前不公认的视力障碍形式。齿膜膜膜可以手术治疗。我们建议，除了综合临床检查外，光学相干断层扫描检查是作为眼科营养不良型1患者的眼科评估的一部分，其视力降低。

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