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首页> 外文期刊>Journal of neurology >Epiretieal membrane: a treatable cause of visual disability in myotoeic dystrophy type 1
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Epiretieal membrane: a treatable cause of visual disability in myotoeic dystrophy type 1

机译：视网膜前膜：可治疗的1型强直性肌营养不良症视力障碍的原因

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A wide range of ocular abnormalities have been documented to occur in patients with myotonic dystrophy type 1. The objectives of this study were to investigate the macular and optic nerve morphology using optical coherence tomography in patients with myotonic dystrophy type 1. A total of 30 myotonic dystrophy type 1 patients and 28 controls were recruited for participation. All participants underwent a thorough ophthalmologic examination, including spectral-domain optical coherence tomography of the macula and retinal nerve fibre layer. Images were reviewed by a retinal specialist ophthalmologist, masked to the diagnosis of the participants. Average macular thickness was significantly greater in the myotonic dystrophy group compared to controls [327.3 um vs. 308.5 um (p < 0.001)]. Macular thickness was significantly greater (p < 0.005) in five of the nine macular regions. The increase in macular thickness was due to the increased prevalence of epiretinal membranes in the myotonic dystrophy patient group (p = 0.0002): 48.2 % of myotonic dystrophy patient eyes had evidence of epiretinal membrane, compared with 12.5 % of control eyes. Examination revealed that 56.7 % of myotonic dystrophy patients had an epiretinal membrane in at least one eye. Visual acuity was reduced due to the presence of epiretinal membrane in six patient eyes and none of the control eyes. The presence of an epiretinal membrane was significantly correlated with increasing age in the patient group. We report an increased prevalence of epiretinal membrane in the myotonic dystrophy type 1 group. This may be a previously under-recognised form of visual impairment in this group. Epiretinal membranes can be treated surgically. We suggest that, in addition to a comprehensive clinical examination, optical coherence tomography examination is implemented as part of an ophthalmological assessment for the myotonic dystrophy type 1 patient with reduced visual acuity.
机译：文献报道1型强直性肌营养不良患者发生了广泛的眼部异常。本研究的目的是使用光学相干断层扫描技术研究1型强直性肌营养不良患者的黄斑和视神经形态。共计30例强直性招募了1型营养不良的患者和28名对照。所有参与者均接受了全面的眼科检查，包括黄斑和视网膜神经纤维层的光谱域光学相干断层扫描。视网膜专家眼科医生对图像进行了复查，掩盖了参与者的诊断。与对照相比，强直性肌营养不良组的平均黄斑厚度明显更大[327.3 um对308.5 um（p <0.001）]。在九个黄斑区中的五个中，黄斑厚度明显更大（p <0.005）。黄斑厚度的增加是由于肌强直性营养不良患者组中前视网膜膜的患病率增加（p = 0.0002）：48.2％的肌强直性营养不良患者眼中有视网膜前膜的证据，而对照眼中这一比例为12.5％。检查显示，有56.7％的肌强直性营养不良患者至少一只眼睛有视网膜上膜。由于六只患者的眼睛中存在视网膜上膜而视力降低，而对照组的一只眼睛均没有。在患者组中，视网膜上膜的存在与年龄的增加显着相关。我们报告在强直性营养不良1型组中视网膜前膜的患病率增加。这可能是该组中先前未被广泛认可的视觉障碍形式。视网膜上膜可以手术治疗。我们建议，除了进行全面的临床检查外，还将光学相干断层扫描检查作为视力下降的1型强直性肌营养不良患者的眼科评估的一部分。

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