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首页> 外文期刊>Journal of neurology >A polysomnographic study in parkinsonian patients treated with intestinal levodopa infusion
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A polysomnographic study in parkinsonian patients treated with intestinal levodopa infusion

机译：肠道左旋多巴输液治疗的帕金森患者的多瘤研究

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摘要

Sleep disorders are very common in advanced Parkinson's disease (PD) and have a significant negative impact on the quality of life of patients. Questionnaire-based studies suggest that sleep quality might improve following levodopa-carbidopa intestinal gel (LCIG) infusion. The objective of this study was to evaluate the impact of LCIG infusion and subsequent oral medication changes on polysomnography (PSG) and sleep symptoms in advanced PD patients. Eleven PD patients underwent PSG at baseline and after 3.8 +/- 1.2 months of LCIG treatment. LCIG infusion therapy was halted during PSG. Patients were assessed with the Unified-PD-rating-Scale and completed the PD-Sleep-Scale-version-2 (PDSS-2), the Epworth Sleepiness Scale and the RBD single question. Subjective sleep quality improved in all patients. PSG showed a reduction of the number of awakenings in sleep, a trend towards a lower apnea-hypopnea index and no change in sleep latency, total sleep time and sleep efficiency. There was a positive correlation between the number of awakenings and PDSS-2 scores for "difficulty staying asleep", "muscle cramps of arms or legs" and "urge to move arms or legs". Motor complications and activities of daily living improved with LCIG. Subjective sleep quality improved significantly and the PSG study showed a less fragmented sleep pattern in advanced PD patients treated with LCIG infusion.
机译：睡眠障碍在先进的帕金森病（PD）中非常普遍，对患者的生活质量产生显着的负面影响。基于调查问卷的研究表明，睡眠质量可能改善左旋多巴肠道肠凝胶（LCIG）输注。本研究的目的是评估LCIG输注和随后的口腔用药变化对高级PD患者的睡眠症状和睡眠症状的影响。 11例PD患者在基线接受PSG，3.8 +/- 1.2个月后LCIG治疗。在PSG期间停止LCIG输液治疗。患者被统一PD-Rating-Rating-Scale评估并完成了PD-Sleep-Scale-version-2（PDSS-2），Epworth Sleepiness Scale和RBD单一问题。所有患者的主观睡眠质量有所改善。 PSG表明睡眠中唤醒的数量减少，令人漏痛呼吸暂停指数较低的趋势，睡眠延迟，总睡眠时间和睡眠效率没有变化。唤醒和PDSS-2的数量与“睡眠困难”，“武器痉挛或腿部”和“移动臂或腿部的呼吸”之间存在正相关性。用LCIG改善日常生活的电机并发症和活动。主观睡眠质量显着提高，PSG研究显示了液化性PD患者的睡眠较小的睡眠模式，治疗LCIG输注治疗。

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