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首页> 外文期刊>Journal of neurology >Head-shaking tilt suppression: a clinical test to discern central from peripheral causes of vertigo
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Head-shaking tilt suppression: a clinical test to discern central from peripheral causes of vertigo

机译:头部摇摆倾斜抑制:从眩晕外围原因辨别中央的临床试验

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摘要

Tilt suppression refers to both tilting the head away from an Earth vertical axis and a reduction of an induced horizontal nystagmus. This phenomenon of reducing an induced horizontal nystagmus involves a circuitry of neurons within the vestibular nuclei and the cerebellum (collectively referred to as velocity storage) and signals from the otolith end organs. Lesions involving this circuitry can disrupt tilt suppression of induced horizontal nystagmus. We investigated the clinical value of combining the horizontal head-shaking nystagmus test with tilt suppression in 28 patients with unilateral peripheral vestibular hypofunction and 11 patients with lesions affecting the central nervous system. Each of the subjects with peripheral vestibular lesions generated an appropriately directed horizontal nystagmus after head shaking that then suppressed the induced angular slow phase velocity on average 52 +/- 17.6% following tilt down of the head. In contrast, patients with central lesions had very little ability to suppress post-head-shaking nystagmus (mean 3.4 +/- 56%). We recommend tilting the head after head shaking as a useful clinical test to assist in the differential diagnosis of vertiginous patients. In the case of unilateral peripheral vestibular hypofunction, head tilt suppresses the induced nystagmus via influence of the otolith organ. In the case of central pathology, the inability to suppress the nystagmus is from lesions impairing the otolith mediation on the velocity storage circuitry.
机译:倾斜抑制是指使头部倾斜远离地球垂直轴和诱导的水平眼压杆菌的减少。减少诱导的水平眼压杆菌的这种现象涉及前庭核和小脑(统称为速度存储)内的神经元的电路,以及来自右右端器官的信号。涉及该电路的病变可以破坏诱导的水平眼压囊的倾斜抑制。我们调查了在28例单侧外周前庭缓冲患者中结合水平头部摇动眼球菌试验与倾斜抑制的临床价值,并影响了影响中枢神经系统的病变患者。在头部摇动后,外周前庭病变的每个受试者产生适当指向的水平眼囊肿,然后在倾斜头部倾斜后平均抑制诱导的角度慢相管速度平均52 +/-17.6%。相比之下,中央病变的患者具有抑制头部摇动后眼球菌(平均3.4 +/- 56%)的能力很少。我们建议在头部摇动后倾斜头部作为有用的临床试验,以帮助患有令人垂直患者的差异诊断。在单侧外周前庭型振动的情况下,头部倾斜通过偏溶液器官的影响抑制了诱导的眼球菌。在中央病理学的情况下,无法抑制眼球震颤的情况来自病变损害速度储存电路上的Otolith中介。

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