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首页> 外文期刊>Journal of neurology >Iron, dopamine, genetics, and hormones in the pathophysiology of restless legs syndrome
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Iron, dopamine, genetics, and hormones in the pathophysiology of restless legs syndrome

机译：铁，多巴胺，遗传学和激素在躁动腿综合征的病理生理学中

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Restless legs syndrome (RLS) is a common, chronic neurologic condition, which causes a persistent urge to move the legs in the evening that interferes with sleep. Human and animal studies have been used to study the pathophysiologic state of RLS and much has been learned about the iron and dopamine systems in relation to RLS. Human neuropathologic and imaging studies have consistently shown decreased iron in different brain regions including substantia nigra and thalamus. These same areas also demonstrate a state of relative dopamine excess. While it is not known how these changes in dopamine or iron produce the symptoms of RLS, genetic and hormone studies of RLS have identified other biologic systems or genes, such as the endogenous opioid and melanocortin systems and BTBD9 and MEIS1, that may explain some of the iron or dopamine changes in relation to RLS. This manuscript will review what is known about the pathophysiology of RLS, especially as it relates to changes in iron, dopamine, genetics, and hormonal systems.
机译：躁动的腿综合征（RLS）是一种常见的慢性神经系统状态，这导致持续的冲动在晚上移动腿部干扰睡眠。已经用于研究RLS的病理生理状态，并且已经了解了与RLS相关的铁和多巴胺系统的致病物理学状态。人类神经病理学和成像研究一直显示在不同的脑区中的掉度减少，包括Imageia Nigra和Thalamus。这些相同的区域还证明了相对多巴胺过量的状态。虽然尚不知道这些多巴胺或铁的变化如何产生RLS的症状，RLS的遗传和激素研究已经鉴定了其他生物系统或基因，例如内源性阿片类药物和黑色素质系统和BTBD9和Meis1，这可能解释一些铁或多巴胺与RLS有关的变化。该稿件将审查RLS的病理生理学所知的内容，特别是它涉及铁，多巴胺，遗传学和激素系统的变化。

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