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首页> 外文期刊>Journal of neurology >Correlation among olfactory function, motors' symptoms, cognitive impairment, apathy, and fatigue in patients with Parkinson's disease
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Correlation among olfactory function, motors' symptoms, cognitive impairment, apathy, and fatigue in patients with Parkinson's disease

机译：帕金森病患者嗅觉功能，电机症状，认知障碍，冷漠和疲劳的相关性

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摘要

Although Parkinson's disease (PD) is usually considered as a movement disorder, it is strongly associated with non-motor symptoms (NMS), including smell and taste dysfunctions, cognitive impairment, apathy, fatigue, and autonomic dysregulation. Olfactory deficit is considered the most common NMS in PD preceding the motor symptoms for years. The aim of this study was to investigate olfactory function, cognitive impairment, apathy, and fatigue in patients with PD in comparison with healthy controls, and subsequently to analyse the correlations between these NMS and motor symptoms severity in subjects with PD. One hundred and forty-seven participants were enrolled (96 PD patients, mean age in years 67.5, SD 7.2; 51 healthy controls; mean age 65.1, SD 11.8). Olfactory function was evaluated using the Sniffin' Sticks test (odor detection threshold, discrimination and identification). The Montreal Cognitive Assessment (MoCA) was used to assess cognitive impairment. Apathy was examined by the self-report version of Starkstein Apathy Scale and fatigue was evaluated with the Parkinson's Disease Fatigue Scale. PD patients showed severe impairment in odor detection threshold, discrimination, and identification compared to healthy controls. Moreover, in PD patients, apathy and fatigue scores were significantly increased, while MoCA scores were decreased in comparison with controls. Multivariate linear regression analyses showed that both apathy and Unified PD Rating Scale (UPDRS) were associated with odor identification, discrimination and Threshold-Discrimination-Identification (TDI) score. In conclusion, our results reported changes in apathy and motor disability as significant predictors in alterations of odor identification, discrimination and TDI score. Furthermore, these data suggest that olfactory dysfunction might progress in tight relation with motor impairment UPDRS but also with non-motor symptoms such as apathy.
机译：虽然帕金森病（Pd）通常被认为是运动障碍，但它与非运动症状（NMS）强烈关联，包括嗅觉和味道功能障碍，认知障碍，冷漠，疲劳和自主相动的失调。嗅觉赤字被认为是电机症状之前的PD中最常见的NMS。本研究的目的是探讨PD患者的嗅觉功能，认知障碍，冷漠和疲劳，并与健康对照进行比较，并且随后分析PD的受试者中这些NMS和电机症状的相关性。注册了一百四十七名参与者（96名PD患者，平均年龄67.5，SD 7.2; 51健康控制;平均65.1，SD 11.8）。使用Sniffin'Signs测试（气味检测阈值，歧视和识别）评估嗅觉功能。蒙特利尔认知评估（MOCA）用于评估认知障碍。通过帕金森疾病的疾病疲劳量表评估了STARKSTEIN冷漠量表的自我报告版本的APATHY。与健康对照相比，PD患者在气味检测阈值，歧视和鉴定方面表现出严重损害。此外，在PD患者中，随着对照的比较，MOCA评分显着增加，而MOCA评分减少。多变量线性回归分析表明，冷漠和统一的PD评级规模（UPDRS）与气味识别，歧视和阈值鉴别识别（TDI）得分有关。总之，我们的结果报告了冷漠和运动残疾的变化，作为气味识别，歧视和TDI评分的变化中的重要预测因子。此外，这些数据表明，嗅功能功能障碍可能与电机损伤updrs紧张的关系，但也具有诸如冷漠的非运动症状。

著录项

  • 来源
    《Journal of neurology》 |2018年第8期|共8页
  • 作者

    Masala Carla; Solla Paolo; Liscia A.; Defazio G.; Saba L.; Cannas A.; Cavazzana A.; Hummel T.; Haehner A.;

  • 作者单位

    Univ Cagliari Dept Biomed Sci Physiol Sect Cagliari Italy;

    Univ Cagliari Movement Disorders Ctr Dept Neurol Inst Neurol Cagliari Italy;

    Univ Cagliari Dept Biomed Sci Physiol Sect Cagliari Italy;

    Univ Cagliari Movement Disorders Ctr Dept Neurol Inst Neurol Cagliari Italy;

    Univ Cagliari AOU Cagliari Italy;

    Univ Cagliari Movement Disorders Ctr Dept Neurol Inst Neurol Cagliari Italy;

    Tech Univ Dresden Interdisciplinary Ctr Smell &

    Taste Dept Otorhinolaryngol Med Fac Carl Gustav;

    Tech Univ Dresden Interdisciplinary Ctr Smell &

    Taste Dept Otorhinolaryngol Med Fac Carl Gustav;

    Tech Univ Dresden Interdisciplinary Ctr Smell &

    Taste Dept Otorhinolaryngol Med Fac Carl Gustav;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经病学;
  • 关键词

    Parkinson's disease; Olfaction; Cognitive ability; Apathy; Fatigue;

    机译：帕金森病;嗅觉;认知能力;冷漠;疲劳;
  • 入库时间 2022-08-20 09:51:28

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