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首页> 外文期刊>Journal of neurology >An evaluation of predictors for success of two-duct ligation for drooling in neurodisabilities
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An evaluation of predictors for success of two-duct ligation for drooling in neurodisabilities

机译：对神经发作流出流口水的两性结扎成功预测因子的评价

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Background Drooling is dependent on various clinical variables. However, while drooling proves refractory to two-duct ligation in 40% of patients, predictors for treatment success are sparse and to date there is little evidence why some respond well while others are non-responders. We aim to find predictors for treatment success and study the effectiveness of two-duct ligation for drooling in neurodisabilities. Methods Fifty-four patients with moderate to severe drooling who had undergone two-duct ligation were screened for inclusion. Four patients were excluded due to missing or unreliable primary outcomes. The average age at the time of surgery was 12 years. Predictors were evaluated for treatment success which was defined as >= 50% visual analog scale for severity of drooling and/or drooling quotient reduction from baseline. Treatment effect was measured after 8 and 32 weeks compared to baseline. Results Age (more mature), adequate posture (no anteflexion), and normal speech are predictors for treatment success. Compared to baseline, drooling quotient was significantly lower at 8 (difference 18.6%, 95% confidence interval 12.3-24.9%) and 32 weeks (difference 10.1%, 95% confidence interval 3.9-16.4%). Compared to baseline, visual analog scale was significantly lower at 8 (difference 45.0, 95% confidence interval 37.0-52.9) and 32 weeks (difference 32.9, 95% confidence interval 25.0-40.7). Conclusions Age, adequate posture, and a normal speech are predictors for treatment success, are easily determined pre-operatively, and help the clinician providing patient-specific probability of treatment success. There is a significant subjective and objective decrease of drooling after two-duct ligation.
机译：背景流口水取决于各种临床变量。然而，虽然流口水证明了40％的患者的两性结扎，但治疗成功的预测因子是稀疏的，迄今为止有一些证据，为什么有些人是非反应者。我们的目标是寻找治疗成功的预测因素，并研究两性连接在神经发作中流口水的有效性。方法筛选54例中度至严重流口水的患者进行筛选。由于缺失或不可靠的主要成果而被排除了四名患者。手术时的平均年龄为12年。评估预测因子进行治疗成功，其定义为> = 50％的视觉模拟规模，用于从基线的流口腔和/或流口水不足的严重程度。与基线相比8和32周后测量治疗效果。结果年龄（成熟），充分姿势（无防止折叠）和正常言论是治疗成功的预测因子。与基线相比，流口水值在8时显着降低（差异18.6％，95％置信区间12.3-24.9％）和32周（差异10.1％，95％置信区间3.9-16.4％）。与基线相比，8（差异45.0,95％置信区间37.0-52.9）和32周（差异32.9,95％置信区间25.0-40.7）相比，视觉模拟规模显着降低。结论年龄，充分的姿势和正常言论是治疗成功的预测因子，易于术语，并帮助临床医生提供患者特异性治疗成功的概率。两道道结扎后流口水存在显着的主观和客观下降。

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