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首页> 外文期刊>Journal of neurology >Characteristics of single ocular motor nerve palsy associated with anti-GQ1b antibody
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Characteristics of single ocular motor nerve palsy associated with anti-GQ1b antibody

机译：与抗GQ1B抗体相关的单眼动机神经麻痹特征

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摘要

To define the prevalence and characteristics of single ocular motor nerve palsy (OMNP) associated with positive serum anti-GQ1b antibody. We performed a prospective multicenter study that recruited 82 patients with single OMNP without identifiable causes from the history and neuroimaging in six neurology clinics of university hospitals. We measured serum anti-GQ1b antibody in all participants. Twelve patients with multiple OMNP and 30 with identifiable causes served as the controls. Overall, the prevalence of anti-GQ1b antibody syndrome was 10% (8/82) in patients with single OMNP and 6% (5/78) in those with single OMNP in isolation. None of the 14 patients with OMNP with identifiable causes showed positive serum anti-GQ1b antibody. The prevalence of anti-GQ1b antibody syndrome was much higher in patients with multiple OMNP than in those with single OMNP (50% vs. 10%, p0.01). Patients with single OMNP and positive anti-GQ1b antibody are younger (42 +/- 16 vs. 58 +/- 15, p0.05) and had a significantly higher frequency of preceding infection (75 vs. 19%, p0.05) and other neurological signs (38 vs. 1%, p0.05) than those with negative antibody. Eight patients with single OMNP and positive serum anti-GQ1b antibody involved the abducens (n=6), trochlear (n=1), or oculomotor nerve (n=1). Single OMNP accompanying other neurological signs and multiple OMNP are more likely to be associated with anti-GQ1b antibody. Anti-GQ1b antibody syndrome should be considered even in patients with single OMNP, especially when antecedent infection was associated in younger patients.
机译：定义与阳性血清抗GQ1B抗体相关的单眼动机神经麻痹（OMNP）的患病率和特征。我们进行了一项前瞻性多中心研究，招募了82名单一OMNP患者，没有历史和神经影像在大学医院的六个神经学诊所的历史和神经影像的可识别原因。我们在所有参与者中测量血清抗GQ1B抗体。十二名患者有多个OMNP和30名具有可识别原因的患者作为对照。总体而言，抗GQ1B抗体综合征的患病率为单个OMNP患者为10​​％（8/82），在单一OMNP中的6％（5/78）中，单一OMNP分离。 14名具有可识别原因的OMNP患者患者显示出阳性血清抗GQ1B抗体。抗GQ1B抗体综合征的患病率在多个OMNP患者中比单个OMNP的患者（50％与10％，P＆ 0.01）。单个OMNP和阳性抗GQ1B抗体的患者较年轻（42 +/- 16 vs.58 +/- 15，P <0.05），并且具有明显较高的感染频率（75 vs.19％，P <0.05）与具有阴性抗体的那些，其他神经迹象（38 vs.1％，P <0.05）。八名单个OMNP和阳性血清抗GQ1B抗体涉及ABDUCENS（n = 6），Trochlear（n = 1）或动眼神经（n = 1）。伴随其他神经迹象和多个OMNP的单个OMNP更可能与抗GQ1B抗体相关。甚至在单一OMNP的患者中，应考虑抗GQ1B抗体综合征，特别是当在较年轻的患者中患有前一种感染时。

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