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首页> 外文期刊>Journal of pediatric hematology/oncology: Official journal of the American Society of Pediatric Hematology/Oncology >Reduced Neutrophil Elastase Activity and Neutrophil Extracellular Traps in Pediatric Acute Myeloid Leukemia May Increase the Rate of Infections
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Reduced Neutrophil Elastase Activity and Neutrophil Extracellular Traps in Pediatric Acute Myeloid Leukemia May Increase the Rate of Infections

机译：减少中性粒细胞弹性蛋白酶活性和中性粒细胞细胞外捕集在儿科急性髓性白血病中可能增加感染率

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摘要

Data on the production of neutrophil extracellular traps (NETs) in leukemia patients are scant. Phagocytosis, hydrogen peroxide, neutrophil elastase and myeloperoxidase enzymatic activity as well as NETs formation were studied in 10 pediatric acute lymphoblastic leukemia and 7 pediatric acute myeloid leukemia (AML) patients after induction chemotherapy. Median neutrophil elastase activity and NETs formation were lower in AML versus acute lymphoblastic leukemia (41% vs. 90%, P=0.005 and 51% vs. 94%, P=0.008, respectively). AML patients had more episodes of febrile neutropenia during the first 2 blocks of treatment (100% vs. 40%, P=0.011) and a trend for more invasive bacterial and fungal infections.
机译：白血病患者中嗜中性粒细胞细胞外疏水阀（网）的数据是狭窄的。 在诱导化疗后，在10个小儿急性淋巴细胞白血病和7个小儿急性髓性白血病（AML）患者中研究了吞噬作用，过氧化物，中性粒细胞酶和髓氧化酶酶活性以及净形成。 中学中性粒细胞弹性蛋白酶活性和净形成在AML与急性淋巴细胞白血病（41％与90％，P = 0.005和51％，分别为94％）。 AML患者在前2块治疗嵌段（100％vs.40％，P = 0.011）和更具侵袭性细菌和真菌感染的趋势中，AML患者在发热中性粒细胞凋亡中具有更多发作。

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