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首页> 外文期刊>Journal of perinatology: Official journal of the California Perinatal Association >Noninvasive validation of tobacco smoke exposure in late pregnancy using end-tidal carbon monoxide measurements.
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Noninvasive validation of tobacco smoke exposure in late pregnancy using end-tidal carbon monoxide measurements.

机译：胎儿一氧化碳测量的妊娠晚期烟草烟雾暴露的非侵入性验证。

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OBJECTIVE: To determine whether exposure to tobacco smoke in late pregnancy can be reliably estimated by measuring carbon monoxide (CO) in the mother and newborn breath. STUDY DESIGN: Sixty-eight mothers and their healthy term singleton newborns, delivered at a university-affiliated community hospital in Jerusalem, were enrolled. End-tidal CO (corrected for inhaled air [ETCOc] was measured with a portable automated bedside CO analyzer. ETCOc, cotinine, and carboxyhemoglobin (COHb) levels were compared in 17 smoking, 31 passively exposed, and 20 nonsmoking mothers and their offspring. RESULTS: The mean +/- SD ETCOc was significantly higher in women who smoked than in passively exposed and nonsmoking mothers (8.42 +/- 5.65 vs 1.95 +/- 0.98 vs 1.33 +/- 0.84 ppm. p < 0.0001, respectively). Newborns whose mothers smoked had higher ETCOc levels than those of infants of passively exposed and nonsmoking mothers (10.0 +/- 7.7 vs 2.51 +/- 1.4 vs 1.74 +/- 0.98 ppm, p < 0.0001, respectively). The number of cigarettes smoked by the mother was significantly correlated with maternal ETCOc (r = 0.755, p < 0.00001), and neonatal ETCOc (r = 0.805, p < 0.00001). Maternal ETCOc was highly correlated with neonatal ETCOc (r = 0.857, p < 0.00001), cotinine (r = 0.645, p < 0.00001), and COHb (r = 0.9, p < 0.00001) levels. Birth weight was significantly associated with neonatal ETCOc (p < 0.006) and maternal ETCOc (p < 0.007). CONCLUSION: ETCOc levels in the newborn are well correlated with maternal smoking. Measurements of newborn ETCOc may be used as a noninvasive means to estimate exposure to maternal tobacco smoke immediately before delivery. These measurements will be useful for patient education and research.
机译：目的：判断是否可以通过测量母亲和新生儿呼吸中的一氧化碳（CO）来可靠地估算在妊娠晚期暴露于烟草烟雾。学习设计：六十八名母亲及其健康的术语单身新生儿，在耶路撒冷的大学附属社区医院交付。通过便携式自动床头段分析仪测量终潮CO（校正吸入空气[etcoc]。etcoC，cotinine和羧杂血红蛋白（Cohb）水平在17个吸烟，31个被动暴露和20个非酿造母亲及其后代进行了比较。结果：比在被动暴露和非莫克兵母亲的女性中，平均+/- SD肉等（8.42 +/- 5.65 Vs 1.95 +/- 0.98 Vs 1.33 +/- 0.84 ppm）。P <0.0001）。母亲吸烟的新生儿具有比被动暴露和非莫斯莫的婴儿（10.0 +/- 7.7与2.51 +/- 1.4与1.74 +/- 0.98 ppm，p <0.0001）的婴儿的水平更高。烟熏的数量母亲与母体休养员显着相关（r = 0.755，p <0.00001）和新生儿etococ（r = 0.805，p <0.00001）。母体休克与新生儿ethoc（r = 0.857，p <0.00001）高度相关（r = 0.857）， cotinine（r = 0.645，p <0.00001）和COHB（r = 0.9，p <0.00001）水平。出生体重与新生儿ETCOC（P <0.006）和母体等妇幼的（P <0.007）显着相关。结论：新生儿中的休克水平与母亲吸烟有很好的相关性。新生儿ETCOC的测量可以用作递送前立即估计暴露于母烟草烟雾的非侵入性手段。这些测量可用于患者教育和研究。

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