Respiratory inhibition of acaricide AKD-2023 and its deacetyl metabolite.

Koura Y; Kinoshita S; Takasuka K; Koura S; Osaki N; Matsumoto S; Miyoshi H

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Respiratory inhibition of acaricide AKD-2023 and its deacetyl metabolite.

机译：催乳剂AKD-2023的呼吸抑制及其脱乙酯代谢物。

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To define the acaricidal mechanism of a new acaricide AKD-2023 [acequinocyl] and its metabolite, DHN (2-hydroxy-3-n-dodecyl-1,4-naphthoquinone), the effects of these compounds on the respiration of flight-muscle mitochondria isolated from house flies [Musca domestica] were investigated. The inhibitory potency of AKD-2023 for succinate and pyruvate oxidation activity was much less than that of DHN. It is suggested that the hydrolyzed metabolite, DHN, is virtually biologically active and inhibits therespiration of mitochondria. It was also shown that the inhibition occurs at the complex III in the mitochondrial electron transfer chain. On the basis of reduction kinetics of cytochromes b and c1, the binding site was shown to be ubiquinol oxidation site (Q0 center) of complex III.

机译：为了定义新的亚氨基丙基-2023γ和代谢物，DHN（2-羟基-3-十二烷基-1,4-萘醌）的杀螨机制，这些化合物对飞行肌肉呼吸的影响从房子隔离的线粒体苍蝇[Musca domestica]被调查了。用于琥珀酸盐和丙酮酸氧化活性的AKD-2023的抑制效力远小于DHN的抑制作用。建议水解的代谢物DHN在实际上是生物学活性的，抑制线粒体的欠款。还表明，在线粒体电子转移链中的复合III中发生抑制。基于细胞色素B和C1的减少动力学，显示粘合位点是络合物III的泛素氧化位点（Q0中心）。

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来源
《Journal of pesticide science》 |1998年第1期|共4页
作者
Koura Y; Kinoshita S; Takasuka K; Koura S; Osaki N; Matsumoto S; Miyoshi H;
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正文语种 eng
中图分类农药工业;农药防治（化学防治）;
关键词
respiration; mitochondria; acaricides; oxidation; nontarget effects; pesticides; agricultural entomology; Musca domestica;

机译：呼吸;线粒体;缩小剂;氧化;非确效应;杀虫剂;农业昆虫学;Musca domestica;

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机译：催乳剂AKD-2023的呼吸抑制及其脱乙酯代谢物。
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Respiratory inhibition of acaricide AKD-2023 and its deacetyl metabolite.

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