首页> 外文期刊>Journal of Parkinson’s disease. >Reduced striatal dopamine synthesis capacity is associated with symptoms of depression in patients with de novo unmedicated Parkinson's disease.
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Reduced striatal dopamine synthesis capacity is associated with symptoms of depression in patients with de novo unmedicated Parkinson's disease.

机译:减少的纹状体多巴胺合成能力与De Novo未描述的帕金森病的患者患者的症状有关。

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Previous studies have suggested that impaired striatal dopamine function might be independently related to depression in patients with Parkinson's disease (PD), but the results are not uniform. In this study, we investigated de novo unmedicated and medicated PD patients with more advanced disease using 18F-fluorodopa-PET. In unmedicated de novo patients, but not in medicated patients, higher depression scores were associated with lower striatal 18F-fluorodopa uptake. These results indicate that impaired striatal dopaminergic function in PD is related to depressive symptoms and that these effects can be observed in de novo patients without the confounding effects of advanced neurodegeneration and medications.
机译:以前的研究表明,脊髓植物多巴胺功能受损可能与帕金森病(PD)患者的抑郁症和抑郁症,但结果并不均匀。 在这项研究中,我们使用18F-氟二戊泮 - 宠物调查了De Novo Unmedicated和药物PD患者,具有更晚期的疾病。 在未描述的De Novo患者中,但不含药物患者,较高的抑郁症分数与较低的脊髓18F-氟二戊聚糖摄取有关。 这些结果表明,PD中的纹状体多巴胺能功能受损与抑郁症状有关,并且可以在德诺患者中观察到这些效果,而没有先进的神经变性和药物的混淆效应。

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