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首页> 外文期刊>Journal of Reproductive Immunology >Natural killer cell activity in women with recurrent miscarriage: Etiology and pregnancy outcome
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Natural killer cell activity in women with recurrent miscarriage: Etiology and pregnancy outcome

机译：自然杀手细胞活性患有复发流产的妇女：病因和怀孕结果

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摘要

This study aimed to evaluate whether natural killer (NK) cell activity was associated with the etiology of recurrent miscarriage (RM), and to evaluate the predictive value of NK cell activity for outcomes of following pregnancies in women with RM. Peripheral NK cell activity was measured in 160 non-pregnant women with a history of two or more miscarriages. This activity was compared according to the etiology of RM and to pregnancy outcomes in women who became pregnant. NK cell activity in women with unexplained RM was significantly higher than that in those with known etiologies of RM. NK cell activity in women whose next pregnancies ended in miscarriage of fetuses with a normal chromosome karyotype (MN) was higher than that in those with live births (p < 0.05). Women with NK cell activity >= 33% had a higher risk for MN (relative risk 3.4, 95% confidence interval 1.3-8.7). An increase in peripheral NK cell activity was associated with MN. This increase might be involved in the pathophysiology underlying RM.
机译：该研究旨在评估自然杀伤（NK）细胞活性是否与复发流产（RM）的病因相关，并评估NK细胞活性的预测值，以患有RM妇女患者的后续妊娠的结果。在160名非孕妇中测量外周NK细胞活性，其中有两个或更多流产的历史。根据RM的病因和妊娠期怀孕的妊娠结果进行比较。具有无法解释的RM的女性中的NK细胞活性显着高于RM的已知病因的妇女。在患有正常染色体核型（Mn）的胎儿流产的下一次怀孕的妇女中的NK细胞活性高于活产物（P <0.05）。 NK细胞活性的女性> = 33％的Mn风险较高（相对风险3.4,95％置信区间1.3-8.7）。外周NK细胞活性的增加与Mn相关。这种增加可能涉及患者依据rm的病理生理学。

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  • 来源
    《Journal of Reproductive Immunology》 |2017年第2017期|共6页
  • 作者

    Ebina Yasuhiko; Nishino Yukari; Deguchi Masashi; Maesawa Yoko; Nakashima Yuki; Yamada Hideto;

  • 作者单位

    Kobe Univ Grad Sch Med Dept Obstet &

    Gynecol Chuo Ku 7-5-1 Kusunoki Cho Kobe Hyogo 6500017;

    Kobe Univ Grad Sch Med Dept Obstet &

    Gynecol Chuo Ku 7-5-1 Kusunoki Cho Kobe Hyogo 6500017;

    Kobe Univ Grad Sch Med Dept Obstet &

    Gynecol Chuo Ku 7-5-1 Kusunoki Cho Kobe Hyogo 6500017;

    Kobe Univ Grad Sch Med Dept Obstet &

    Gynecol Chuo Ku 7-5-1 Kusunoki Cho Kobe Hyogo 6500017;

    Kobe Univ Grad Sch Med Dept Obstet &

    Gynecol Chuo Ku 7-5-1 Kusunoki Cho Kobe Hyogo 6500017;

    Kobe Univ Grad Sch Med Dept Obstet &

    Gynecol Chuo Ku 7-5-1 Kusunoki Cho Kobe Hyogo 6500017;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 妇科学;
  • 关键词

    Miscarriage; Natural killer cell; Pregnancy;

    机译：流产;天然杀手细胞;怀孕;

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