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首页> 外文期刊>Journal of Reproductive Immunology >Interleukin 11 is upregulated in preeclampsia and leads to inflammation and preeclampsia features in mice
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Interleukin 11 is upregulated in preeclampsia and leads to inflammation and preeclampsia features in mice

机译：白细胞介素11在预口度血症中上调，并导致小鼠的炎症和前普拉曼血症特征

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摘要

Preeclampsia is a dangerous pregnancy complication, which is often associated with fetal growth restriction and can have serious life-long effects for both mother and baby. While the establishment of the placenta in the first trimester is the sentinel event in the development of preeclampsia little is known of the critical mechanisms of placentation that lead to the syndrome. Locally produced inflammatory cytokines are thought to play a role in the development of preeclampsia. This review summarizes the evidence that interleukin 11 is dysregulated in preeclampsia and contributes to the initiation of preeclampsia via effects on placentation. It discusses the benefits and drawbacks of targeting IL11 as a novel treatment option for preeclampsia.
机译：预填血症是一种危险的妊娠并发症，其通常与胎儿生长限制有关，并且对母亲和婴儿的效果都具有严重的终身影响。 虽然孕期在孕期的胎盘的建立是哨兵事件在开发前普利坦斯的事件毫无少地征于导致综合征的临床临界机制。 局部产生的炎性细胞因子被认为在Preclampsia的发展中发挥作用。 本综述总结了白细胞介素11在预胰岛素中的表现困难，并通过对映射的影响有助于引发预坦克敏。 它讨论了靶向IL11作为Preclampsia的新型治疗选择的益处和缺点。

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