• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of renal nutrition: the official journal of the Council on Renal Nutrition of the National Kidney Foundation >Severe dietary protein restriction in overt diabetic nephropathy: Benefits or risks?
【24h】

Severe dietary protein restriction in overt diabetic nephropathy: Benefits or risks?

机译：明显糖尿病肾病的严重膳食蛋白质限制：福利或风险？

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE: To evaluate whether restricting protein intake may delay the progression of chronic renal failure caused by overt diabetic nephropathy and also whether this increases the risk of malnutrition. DESIGN: Prospective clinical trial. SETTING: Nephrology outpatients. PATIENTS: Sixty-nine patients (32 affected by type 1 and 37 by type 2 diabetes, all treated with insulin) affected by both overt diabetic nephropathy and hypertension. INTERVENTION: The study was started once hypertension and glycemia had been under control for at least 3 months. Two groups of patients, matched for similar mean glomerular filtration rate value and nutritional status, were studied: a low-protein diet (0.6 g/kg/d) was randomly prescribed to 35 patients, whereas in the other 34 patients a free diet intake was maintained for 12 months. Main Outcome Measure: Renal function and nutritional status. RESULTS: The protein intake was significantly different in the 2 groups of patients, whereas the average decline of glomerular filtration rate during the follow-up was comparable. In the low-protein diet group, serum prealbumin concentration significantly decreased after 9 months, whereas serum albumin decreased at the end of the study. CONCLUSION: Severe dietary protein restriction does not seem to delay the progression of renal disease in patients with overt diabetic nephropathy, whereas it may induce malnutrition.
机译：目的：评价限制性蛋白质摄入是否可能延迟患有明显糖尿病肾病引起的慢性肾功能衰竭的进展，以及这是否会增加营养不良的风险。设计：前瞻性临床试验。设置：肾病门诊。患者：六十九名患者（32型患者受到1型糖尿病，均用胰岛素治疗，受外观糖尿病肾病和高血压影响。干预：开始曾经高血压和糖血症的研究开始至少3个月。研究了两组患者，符合类似的平均肾小球过滤率值和营养状况，呈现出低蛋白质饮食（0.6克/ kg / d）随机处方，而另外34名患者免费饮食摄入量维持12个月。主要结果措施：肾功能和营养状况。结果：2组患者中蛋白质摄入显着差异，而随访期间的肾小球过滤速率的平均下降是可比的。在低蛋白质饮食组中，9个月后，血清白敏突出浓度明显下降，而血清白蛋白在研究结束时降低。结论：严重的膳食蛋白质限制似乎似乎延迟了患有外观糖尿病肾病患者肾病的进展，而它可能会诱导营养不良。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号