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首页> 外文期刊>Journal of renal nutrition: the official journal of the Council on Renal Nutrition of the National Kidney Foundation >How to Prevent Renal Cachexia? A Clinical Randomized Pilot Study Testing Oral Supplemental Nutrition in Hemodialysis Patients With and Without Human Immunodeficiency Virus Infection
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How to Prevent Renal Cachexia? A Clinical Randomized Pilot Study Testing Oral Supplemental Nutrition in Hemodialysis Patients With and Without Human Immunodeficiency Virus Infection

机译：如何防止肾脏肠病？ 血液透析患者口腔补充试验研究检测血液透析患者的临床随机试验研究

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Objective End-stage renal disease associates with catabolism and sarcopenia. Hypothetically, peroral supplemental nutrition over 6?months prevents catabolism in hemodialysis patients. Design Prospective randomized pilot study ( ClinicalTrials.gov Identifier: NCT00687050). Subjects Twenty-three hemodialysis patients (15 males and 7 females) with or without human immunodeficiency virus (HIV) infection of 2 ambulatory hemodialysis centers. Intervention HIV-positive hemodialysis patients ( n ?=?7, Group 1) were started on supplemental nutrition drinks (250?kcal/day), HIV-negative hemodialysis patients (n?=?16, Group 2) were randomized to supplemental nutrition drinks (250?kcal/day) or received none. Main Outcome Measures Body impedance analysis, anthropometric measures, magnetic resonance imaging results for mid-iliopsoas muscle cross-sectional area and laboratory parameters including albumin, cytokines at baseline, and at 6?months follow-up. Results Seven patients in Group 1 (mean age: 50.6?±?9.6?years) and 16 patients in Group 2 (mean age: 54.0?±?13.3?years) were recruited. Serum creatinine (Group 1: 6.4?±?3.0?mg/dL; Group 2: 10.7?±?2.5?mg/dL; P ? P ? P ? Conclusions A new oral supplemental nutrition over 6?months had no treatment effect in surviving HIV-positive hemodialysis patients or in maintenance hemodialysis patients without HIV infection. The limitations of this study were small study size and unexpected high mortality among HIV-positive hemodialysis patients.
机译：目标末期肾病与分解代谢和肌肉疾病联系。假设，超过6个月的产卵补充营养可防止血液透析患者分解代谢。设计前瞻性随机试验研究（ClinicalTrials.gov标识符：NCT00687050）。受试者的二十三名血液透析患者（15名男性和7名女性），或没有人类免疫缺陷病毒（HIV）感染2个动态血液透析中心。干预艾滋病毒阳性血液透析患者（n？=β7，第1组）开始于补充营养饮料（250 kcal /天），HIV阴性血液透析患者（n？=β16，第2组）被随机化以补充营养饮料（250？kcal / day）或没有收到。主要结果测量身体阻抗分析，人类测量措施，磁共振成像结果，用于中髂肌剖视区和实验室参数，包括白蛋白，基线细胞因子，6？几个月随访。结果1组7例患者（平均年龄：50.6？±9.6岁）和第2组16名患者（平均年龄：54.0？±13.3岁）。血清肌酐（第1组：6.4？±3.0？mg / dl;第2组：10.7？±2. 2.5？mg / dl; p？p？p？结论新的口腔补充营养超过6？个月没有治疗效果生存艾滋病毒阳性血液透析患者或维持血液透析患者，无HIV感染。本研究的局限性是艾滋病毒阳性血液透析患者的小型研究规模和意外的高死亡率。

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