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首页> 外文期刊>Journal of strength and conditioning research >Moderate-Intensity Strength Exercise to Exhaustion Results in More Pronounced Signaling Changes in Skeletal Muscles of Strength-Trained Compared With Untrained Individuals
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Moderate-Intensity Strength Exercise to Exhaustion Results in More Pronounced Signaling Changes in Skeletal Muscles of Strength-Trained Compared With Untrained Individuals

机译：与未经训练的人相比，中等强度锻炼耗尽耗尽导致强度训练的骨骼肌中的更明显的信号变化

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Lysenko, EA, Popov, DV, Vepkhvadze, TF, Sharova, AP, and Vinogradova, OL. Moderate-intensity strength exercise to exhaustion results in more pronounced signaling changes in skeletal muscles of strength-trained compared with untrained individuals. J Strength Cond Res 34(4): 1103-1112, 2020-The aim of our investigation was to compare the response pattern of signaling proteins and genes regulating protein synthesis and degradation in skeletal muscle after strength exercise sessions performed to volitional fatigue in strength-trained and untrained males. Eight healthy recreationally active males and 8 power-lifting athletes performed 4 sets of unilateral leg presses to exhaustion (65% 1 repetition maximum). Biopsy samples of m. vastus lateralis were obtained before, 1 and 5 hours after cessation of exercise. Phosphorylation of p70S6k(Thr389), 4EBP1(Thr37/46), and ACC(Ser79) increased, whereas phosphorylation of eEF2(Thr56) and FOXO1(Ser256) decreased only in the trained group after exercise. Expression of DDIT4, MURF1, and FOXO1 mRNAs increased and expression of MSTN mRNA decreased also only in the trained group after exercise. In conclusion, moderate-intensity strength exercise performed to volitional fatigue changed the phosphorylation status of mTORC1 downstream signaling molecules and markers of ubiquitin-proteasome system activation in trained individuals, suggesting activation of protein synthesis and degradation. In contrast to the trained group, signaling responses in the untrained group were considerably less pronounced. It can be assumed that the slowdown in muscle mass gain as the athletes increase in qualification cannot be associated with a decrease in the sensitivity of systems regulating protein metabolism, but possibly with inadequate intake or assimilation of nutrients necessary for anabolism. Perhaps, the intake of highly digestible protein or protein-carbohydrate dietary supplements could contribute to the increase in muscle mass in strength athletes.
机译：Lysenko，EA，Popov，DV，Vepkhvadze，TF，Sharova，AP和Vinogradova，OL。与未经训练的人相比，中等强度强度锻炼耗尽导致强度训练的骨骼肌的更加明显的信号传导变化。 J强度COND RES 34（4）：1103-1112,2020-我们调查的目的是比较信号蛋白和基因调节蛋白质合成和降解在强度运动的强度运动后骨骼肌肉中的响应模式和降解 - 训练有素和未经训练的男性。八个健康的休闲活动的男性和8名电动升降运动员表演了4套单侧腿部耗尽（最大值65％1重复）。 m的活检样本。在停止运动后1和5小时之前获得了夸张的左侧。 P70S6K（THR389），4EBP1（THR37 / 46）和ACC（SER79）的磷酸化增加，而EEF2（THR56）和FOXO1（SER256）的磷酸化仅在运动后仅在培训的组中降低。 DDIT4，MERF1和FOXO1 mRNA的表达增加和MSTN mRNA的表达也仅在运动后的培训组中降低。总之，对激活疲劳进行的中等强度强度运动改变了培训的个体中遍突蛋白 - 蛋白酶体系系统活化的MTORC1下游信号分子和标记的磷酸化状态，表明蛋白质合成和降解的激活。与训练有素的群体相比，未经培训的群体中的信令响应相当不明显。可以假设肌肉质量收益的放缓随着运动员增加资格的增加不能与系统调节蛋白质代谢的敏感性的降低相关，但可能不充分的摄入或同化合成代谢所需的营养素。也许，高度消化蛋白质或蛋白质 - 碳水化合物膳食补充剂的摄入可能导致力量运动员的肌肉质量增加。

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