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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Changes in serum growth factors in stroke rehabilitation patients and their relation to hemiparesis improvement
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Changes in serum growth factors in stroke rehabilitation patients and their relation to hemiparesis improvement

机译：中风康复患者血清生长因子的变化及其与血逐改进的关系

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摘要

Predicting recovery from hemiparesis after stroke is important for rehabilitation. A few recent studies reported that the levels of some growth factors shortly after stroke were positively correlated with the clinical outcomes during the chronic phase. The aim of this study was to examine the relationships between the serum levels of growth factors (vascular endothelial growth factor [VEGF], insulin-like growth factor-I [IGF-I], and hepatocyte growth factor [HGF]) and improvement in hemiparesis in stroke patients who received rehabilitation in a postacute rehabilitation hospital. Subjects were 32 stroke patients (cerebral infarction: 21 and intracerebral hemorrhage [ICH]: 11). We measured serum levels of VEGF, IGF-I, and HGF and 5 items of the Stroke Impairment Assessment Set (SIAS) for hemiparesis on admission and at discharge. Age-matched healthy subjects (n = 15) served as controls. Serum levels of VEGF and HGF in cerebral infarct patients on admission were higher than those in control subjects, and the serum levels of IGF-I in stroke patients were lower than those in controls. The level of HGF in ICH patients on admission was negatively correlated with gains in SIAS, and higher outliers in HGF concentration were correlated with lower gains in SIAS. Focusing on the extremely high levels of these factors may be a predictor of the low recovery from hemiparesis after stroke.
机译：在中风后预测从偏瘫的回收对于康复至关重要。最近的一些研究报告说，在慢性相期间，中风后不久的一些生长因子的水平与临床结果呈正相关。本研究的目的是检查血清生长因子水平（血管内皮生长因子[VEGF]，胰岛素样生长因子-I [IGF-I]和肝细胞生长因子[HGF]）之间的关系及改善在突发康复医院接受康复的中风患者的偏瘫。受试者是32例中风患者（脑梗塞：21和脑内出血[ICH]：11）。我们测量了VEGF，IGF-1和HGF的血清水平，以及5项中风损伤评估组（SIAS）用于入院和放电的血清。年龄匹配的健康受试者（n = 15）作为对照。入院脑梗死患者中VEGF和HGF的血清水平高于对照组，卒中患者中IGF-1的血清水平低于对照组。入院患者中的HGF水平与SIAS的增益负相关，HGF浓度的更高异常因素与SIAS的降低收益相关。专注于极高的这些因素可以是中风后偏瘫恢复的预测因子。

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