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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Statin Use and the Risk of Dementia in Patients with Stroke: A Nationwide Population-Based Cohort Study
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Statin Use and the Risk of Dementia in Patients with Stroke: A Nationwide Population-Based Cohort Study

机译：他汀类药物的使用和中风患者痴呆风险：全国范围的人口队列队列研究

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Background:Patients with stroke have an increased risk of?dementia. Some studies have found that statin use might lower the risk of incident dementia; however, there is still a lack of data from patients with stroke. Therefore, the aim of our study was to investigate the impact of statin use on the risk of dementia in patients with stroke. MethodsWe used the National Health Insurance Research Database in Taiwan to identify 14,807 patients diagnosed with stroke from 1997 to 2005. These patients were classified as statin users and nonusers. Propensity score matching was performed to balance selected confounders between the statin users and nonusers. Cox proportional hazard regression models were used to evaluate the association between statin use and the risk of dementia. ResultsDuring the follow-up period (median, 7.5 years), 1895 patients were diagnosed with incident dementia. Statin use was associated with a significantly lower incidence of dementia (adjusted hazard ratio, .81; 95% confidence interval, .73-.89) than nonuse was. In particular, lipophilic and high-potency statins were associated with lower risk of dementia. Statin exposure duration was inversely related to the risk of dementia (P< .001 for the trend). No significant effect modification for the relationship between statin use and the risk of dementia was found for either age or sex. ConclusionIn this nationwide cohort study, statin use was associated with decreased risk of dementia among patients with stroke. The use of high-potency statins, lipophilic statins, and prolonged exposure to statins may be associated with greater benefits.
机译：背景：中风的患者具有增加的风险？痴呆风险。一些研究发现他汀类药物的使用可能降低入射痴呆的风险;然而，患有中风的患者仍有缺乏数据。因此，我们的研究目的是探讨他汀类药物对卒中患者痴呆风险的影响。方法采用台湾国民健康保险研究数据库，从1997年至2005年鉴定了14,807名患者诊断的中风患者。这些患者被归类为他汀类药物和非用户。倾向进行分数匹配以平衡他汀类药物和非用户之间的选定混血。 Cox比例危险回归模型用于评估他汀类药物使用与痴呆风险之间的关联。导致后续期间（中位数，7.5岁），1895名患者被诊断出入射痴呆症。他汀类药物的用途与显着降低的痴呆发病率（调整后的危险比，.81; 95％置信区间，.73-.89）的痴呆症发生率明显低于非使用。特别地，亲脂性和高效他汀类药物与痴呆的风险较低有关。他汀类药物暴露持续时间与痴呆症的风险相反（趋势的P <.001）。没有针对他汀类药物的关系和痴呆症之间的关系的显着效果改性，为期年龄或性别都被发现。结论在全国范围内的研究中，他汀类药物使用与中风患者患患者的痴呆风险降低有关。使用高效他汀类药物，亲脂性他汀类药物和长期暴露于他汀类药物可能与更大的益处相关。

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