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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Increased Spot Urine Albumin-to-Creatinine Ratio and Stroke Incidence: A Systematic Review and Meta-Analysis
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Increased Spot Urine Albumin-to-Creatinine Ratio and Stroke Incidence: A Systematic Review and Meta-Analysis

机译：增加尿白霉素至肌酐比例和中风发病率：系统审查和荟萃分析

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Objective: This study aimed to clarify the association between an increased spot urine albumin-to-creatinine ratio (UACR) and the risk of stroke. Methods: We performed a systematic review and meta-analysis of cohort studies, case-control studies, and ancillary data randomized controlled trials (RCTs), which were treated as cohorts in this study, and estimated the association between albuminuria, as measured with the UACR, and the risk of stroke. We performed a comprehensive search of PubMed, Embase, and the Cochrane Library and conducted a systematic review and cumulative meta-analysis of cohort studies with a cross-sectional with prospective design in which stroke incidence was reported and the baseline UACR was measured. Ancillary data from RCTs were also included as part of the cohort study. We studied the characteristics of the participants, quality scores and risk ratios (RR, with confidence intervals, CI) of stroke associated with normal and high UACRs, and we synthesized the data via a meta-analysis. Results: Twelve eligible studies including a total of 32,888 participants and 3,944 cases of stroke were identified. A high UACR (>30 mg/mmol) increased the risk of stroke by 1.67 times (RR: 1.67, 95% CI: 1.49-1.86, P<0.001 I-2 = 26%). The results were not different between Asian and non-Asian patients (RR: 1.64, 95% CI: 1.41-1.91, P<0.001, I-2 = 23% compared with RR: 1.67, 95% CI: 1.50-1.85, P<0. 00, I-2 = 39%) or between subgroups classified by old age (RR: 1.61, 95% CI: 1.39-1.88, P<0.001, I-2 = 34% compared with RR: 1.68, 95% CI: 1.52-1.87, P<0.001, I-2 = 13%). A sensitivity analysis did not significantly change the results. Conclusion: The incidence of stroke increased significantly in the high UACR group compared with the normal UACR group. The UACR could be a clinical addition for the early indication of high-risk stroke patients.
机译：目的：本研究旨在阐明增加的尿液白蛋白与肌酐比率（UACR）与中风风险之间的关联。方法：我们对群组研究，病例对照研究和辅助数据随机对照试验（RCTS）进行了系统审查和荟萃分析，该试验（RCT）被视为该研究的群组，并估计白蛋白尿素之间的关联，与UACR，以及中风的风险。我们对PubMed，Embase和Cochrane图书馆进行了全面搜索，并对群组研究进行了系统审查和累积荟萃分析，其横截面具有横截面，其中报告了中风发病率并且测量基线UACR。来自RCTS的辅助数据也被包括作为队列研究的一部分。我们研究了与正常和高UACR相关的中风的参与者，质量评分和风险比（RR，置信区间，CI）的特征，我们通过META分析综合了数据。结果：12种符合条件的研究，包括共32,888名参与者和3,944例中风病程。高UACR（> 30mg / mmol）增加了卒中风险1.67次（RR：1.67,95％CI：1.49-1.86，P <0.001 I-2 = 26％）。亚洲和非亚洲患者之间的结果不含量（RR：1.64,95％CI：1.41-1.91，P <0.001，I-2 = 23％与RR：1.67,95％CI：1.50-1.85，P <0.00，I-2 = 39％）或由较大年龄分类的亚组（RR：1.61,95％CI：1.39-1.88，P <0.001，I-2 = 34％与RR：1.68,95％相比CI：1.52-1.87，P <0.001，I-2 = 13％）。敏感性分析没有显着改变结果。结论：与正常UACR组相比，高UACR组中风发病率显着增加。 UACR可以是早期征兆的高危卒中患者的临床增加。

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