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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >The Relationship between Neutrophil-to-Lymphocyte Ratio and Aortic Arch Calcification in Ischemic Stroke Patients
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The Relationship between Neutrophil-to-Lymphocyte Ratio and Aortic Arch Calcification in Ischemic Stroke Patients

机译：缺血性脑卒中患者中性粒细胞对淋巴细胞比与主动脉弓钙化的关系

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Background: Inflammation plays a central role in atherogenesis and artery calcification. Although neutrophil-to-lymphocyte ratio (NLR) has been introduced as an inflammatory marker for atherosclerosis, the relationship between NLR and aortic arch calcification (AAC) has not been studied. This study aimed to determine the association between NLR and AAC. Methods: A total of 749 participants were enrolled. Demographic and clinical data were collected. Degree of AAC in each enrolled patient was determined with Agatston method based on a neck computed tomography angiography. NLR was divided into 4 groups according to quartile values. Generalized linear model (ordinal probit) was performed to assess the association between NLR quartiles and severity of AAC. Results: There were 151 (20.2%), 153 (20.4%), and 445 (59.4%) patients classified as without AAC, with mild AAC, and with severe AAC, respectively. Patients with severe AAC had the highest NLR values (2.37[1.79-3.42] versus 2.29[1.55-2.96] versus 2.17[1.64-2.91], P = .025) compared to patients without AAC and with mild AAC. In age- and sex-adjusted models, patients with the highest NLR (quartile 4) were correlated with severer AAC (beta = .348 +/- .128, P = .006) compared to those with the lowest levels (quartile 1). The correlation between NLR quartile 4 and severer AAC still existed (beta = .335 +/- .129, P = .009) in multivariable-adjusted model. Conclusions: This study suggested that NLR may reflect the severity of AAC. NLR may be considered as a valuable predictor of the degree of artery calcification. (C) 2017 National Stroke Association. Published by Elsevier Inc. All rights reserved.
机译：背景：炎症在体育血肿和动脉钙化中起着重要作用。虽然已经引入了中性粒细胞至淋巴细胞比（NLR）作为动脉粥样硬化的炎症标志物，但尚未研究NLR和主动脉弓钙化（AAC）之间的关系。本研究旨在确定NLR和AAC之间的关联。方法：注册了749名参与者。收集人口统计和临床数据。使用基于颈部断层造影血管造影的Agatston方法测定每次注册患者中AAC的AAC度。根据四分位数值将NLR分成4组。进行广义线性模型（序序机）进行评估NLR四分位数与AAC严重程度之间的关联。结果：151例（20.2％），153（20.4％）和445名（59.4％）患者分为没有AAC，分别具有轻度AAC和严重AAC。严重AAC的患者具有最高的NLR值（2.37 [1.79-3.42]，与2.17 [1.64-2.91]，P = .025）与没有AAC和轻度AAC的患者相比。在年龄和性别调整的模型中，与最低水平（四分位数1）的人相比，患有最高NLR（四分位数4）的患者（Beta = .348 +/- .128，p = .128，p = .128，p = .128，p =。 。 NLR四分位数4和SELERER AAC之间的相关性在多变量调整的模型中存在（beta = .335 +/- .129，p = .129）。结论：本研究表明NLR可能反映AAC的严重程度。 NLR可以被认为是动脉钙化程度的有价值的预测因子。 （c）2017国家冲程协会。由elsevier Inc.保留所有权利发布。

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