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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Biomarkers of Functional Outcome in Intracerebral Hemorrhage: Interplay between Clinical Metrics, CD163, and Ferritin
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Biomarkers of Functional Outcome in Intracerebral Hemorrhage: Interplay between Clinical Metrics, CD163, and Ferritin

机译：脑出血中功能结果的生物标志物：临床指标，CD163和铁蛋白之间的相互作用

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Background: Intracerebral hemorrhage (ICH) is associated with neurological decline and poor prognosis. Although many etiologic models have been explored, secondary damage caused by continued inflammation and iron exposure from red blood cell lysis may explain poor outcomes at distant follow-up. Examining serum samples of patients with ICH for biomarkers of iron physiology may yield relationships between iron exposure and functional outcomes. Methods: The following study retrospectively evaluated 41 patient serum samples obtained 1 day and 7 days post-ictus for CD163, ferritin, and hepcidin concentrations. Functional outcomes, using the modified Rankin Scale, were dichotomized into good (0-3) and poor (4-6). Correlation analysis and logistic regression were used to explore relationships between biomarker values, clinical metrics (such as ICH Score), and functional outcomes at 3 and 12 months. Results: Clinical metrics (Acute Physiology and Chronic Health Evaluation II score, ICH Score, and National Institutes of Health Stroke Scale) were correlated with elevated ferritin levels 7 days postictus. Furthermore, it was found that mean CD163 levels on day 1 were significantly associated with functional outcomes at 3 and 12 months; mean serum ferritin concentrations on days 1 and 7 were elevated in those with poor outcomes at 3 months, and day 7 levels were independently correlated with 12-month outcomes. Conclusion: Although this study serves to contribute to a growing body of evidence that CD163 and ferritin are biomarkers of functional outcomes, prospective cohort studies may clarify the role of iron-related inflammatory biomarkers as they pertain to neurological decline in patients with ICH. (C) 2017 National Stroke Association. Published by Elsevier Inc. All rights reserved.
机译：背景：脑出血（ICH）与神经系统下降和预后不良有关。虽然已经探索了许多病因模型，但由红细胞裂解的持续炎症和铁暴露引起的继发损害可以解释遥远随访的差。检查ICH患者的血清样品用于铁生理学的生物标志物，可能会产生铁暴露和功能结果之间的关系。方法：下列研究回顾性评估了41例患者血清样品1天和第7天的CD163，铁蛋白和肝蛋白浓度的7天。使用改进的Rankin规模的功能结果被二分作化为良好（0-3）和差（4-6）。相关分析和逻辑回归用于探讨生物标志物值，临床指标（如ICH评分）之间的关系，以及3和12个月的功能结果。结果：临床指标（急性生理学和慢性健康评估II得分，ICH评分和国家卫生卒中量表）与升高的铁蛋白水平7天后升高。此外，发现第1天的平均CD163水平与3和12个月的功能结果显着相关;在第1天和第7天的平均血清铁蛋白浓度在3个月内较差的那些升高，第7天水平与12个月的结果无关。结论：虽然这项研究有助于促进越来越多的证据表明CD163和铁蛋白是功能结果的生物标志物，但前瞻性队列研究可以阐明铁相关炎症生物标志物的作用，因为它们涉及ICH患者的神经系统下降。 （c）2017国家冲程协会。由elsevier Inc.保留所有权利发布。

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