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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Impact of Hypertriglyceridemia on Carotid Stenosis Progression under Normal Low-Density Lipoprotein Cholesterol Levels
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Impact of Hypertriglyceridemia on Carotid Stenosis Progression under Normal Low-Density Lipoprotein Cholesterol Levels

机译：高甘油脂血症对正常低密度脂蛋白胆固醇水平下颈动脉狭窄进展的影响

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Background: Dyslipidemia is a well-known risk factor for carotid stenosis progression, but triglycerides have attracted little attention. The aim of this study was to assess if serum triglycerides affect progression of carotid stenosis in patients with well-controlled low-density lipoprotein cholesterol (LDL-C) levels. Methods: This is a retrospective study in a single hospital consisting of 71 Japanese patients with internal carotid artery stenosis greater than or equal to 50% and normal serum LDL-C levels who underwent angiographic examination with or without the resultant carotid artery stenting or endarterectomy from 2007 to 2011, and were subsequently followed up for 4 years. Clinical factors including fasting serum triglyceride values were compared between the progression (>= 10% increase in degree of carotid stenosis on ultrasonography) and the nonprogression groups. Results: During 4 years, 15 patients (21.1%) had carotid stenosis progression on either side. Cox regression analysis demonstrated that symptomatic cases (hazard ratio [HR], 4.327; P = .019), coexisting intracranial arteriosclerotic stenosis (HR, 5.341; P = .005), and hypertriglyceridemia (HR, 6.228; P = .011) were associated with subsequent progression of carotid stenosis. Kaplan-Meier plots demonstrated that the progression-free survival rate was significantly higher in patients without hypertriglyceridemia and intracranial arteriosclerotic stenosis at baseline. Conclusions: Among patients with moderate to severe carotid stenosis and well-controlled LDL-C, hypertriglyceridemia was an important risk factor for progression of carotid stenosis irrespective of surgical treatments. It would be worthwhile to test if triglyceride-lowering medications suppress carotid stenosis progression.
机译：背景：血脂异常是颈动脉狭窄进展的一个众所周知的危险因素，但甘油三酯都没有引起多少关注。本研究的目的是评估如果血清甘油三酯影响颈动脉狭窄的进展患者良好控制的低密度脂蛋白胆固醇（LDL-C）的水平。方法：这是在由71名日本患者颈内动脉狭窄更大单个医院的回顾性研究大于或等于50％，并且谁接受血管造影检查用或不用所得颈动脉支架或动脉内膜切除术从正常的血清LDL-C水平2007年至2011年，随后随后随访4年。临床因素，包括空腹血清甘油三酯值的进展（> = 10％的增加在超声颈动脉狭窄度）和非进展组之间进行比较。结果：在4年，15例（21.1％）对任一侧颈动脉狭窄进展。 Cox回归分析证实了症状的病例[风险比（HR]，4.327; P = 0.019），共存颅内动脉硬化狭窄（HR，5.341; P = 0.005），和高甘油三酯血症（HR，6.228; P = 0.011）为与随后的颈动脉狭窄进展相关。卡普兰 - 梅尔图显示，无进展生存率患者显著较高的是没有高甘油三酯血症和动脉硬化颅内狭窄的基线。结论：在患者的中度至重度颈动脉狭窄和良好控制LDL-C，高甘油三酯血症是颈动脉狭窄不考虑手术治疗的进展的一个重要危险因素。这将是值得的测试，如果降低甘油三酯的药物抑制颈动脉狭窄的进展。

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