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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >M2 Monocyte Microparticles Are Increased in Intracerebral Hemorrhage
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M2 Monocyte Microparticles Are Increased in Intracerebral Hemorrhage

机译：M2单核细胞微粒在脑出血中增加

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Background Intracerebral hemorrhage (ICH) is a severe neurologic condition with no proven treatment. Recent evidence suggests that monocytes, a heterogenous group of cells with M1 and M2 phenotypes, contribute to secondary damage following ICH. Microparticles are vesicles .1-1?μm in size that are released from cells. We hypothesized that M1 and M2 monocyte microparticles (mMP) would be differentially expressed in ICH cases and controls. Methods In a single-center, prospective, observational study, consecutive ICH cases were enrolled within 12 hours of symptom onset. Age (±5 years)-, race-, and sex-matched controls were recruited. M1 and M2 mMP numbers were determined in plasma samples using flow cytometry and protein biomarkers using standardized assays. The Mann–Whitney U test compared M1 and M2 mMP counts between cases and controls. Standardized regression coefficients compared M1 and M2 mMP with C-reactive protein (CRP) and serum amyloid A (SAA). Results Nineteen ICH case-control pairs were enrolled. The median number of M1 mMP was not significantly different between ICH cases (8.63?×?10 7 /milliliter (mL)) compared with controls (8.64?×?10 7 /mL), ( P ?=?.525). The median number of M2 mMP was significantly higher in ICH cases (1.61?×?10 6 /mL) compared with controls (4.46?×?10 5 /mL) ( P ?=?.027). There were no significant associations for M1 or M2 mMP with CRP or SAA. Conclusion Higher numbers of M2 mMP in ICH cases compared with controls is hypothesis generating. It may represent differences in the chronic inflammatory status in patients susceptible to ICH, such as cellular activation or apoptosis. Further research is needed, including serial plasma samples, to elucidate the pathophysiology of monocytes and mMP following ICH. ]]>
机译：背景技术脑出血（ICH）是一种严重的神经系统病症，没有经过验证的治疗。最近的证据表明，单核细胞，具有M1和M2表型的异细胞组，有助于继电器后的二次损伤。微粒是囊泡.1-1≤μm尺寸，尺寸从细胞中释放。我们假设M1和M2单核细胞微粒（MMP）将在ICH病例和对照中差异表达。方法在单中心，前瞻性，观察性研究中，连续的ICH病例在症状发作的12小时内注册。年龄（±5年） - 招募，种族和性别匹配的控制。使用标准化测定的流式细胞术和蛋白质生物标志物在血浆样品中测定M1和M2MMP数。 Mann-Whitney U测试在案例和控制之间进行了M1和M2 MMP计数。标准化的回归系数与C-反应蛋白（CRP）和血清淀粉样蛋白A（SAA）进行了标准化的M1和M2MMP。结果19个ICH病例对照对进行了注册。与对照（8.64×10 7 / mL）相比，M1 mMP的中位数的M1mMP（8.63？×10 7 /毫升（ml））没有显着差异（p？= 525）。与对照相比，ICH病例（1.61？×10 6 / mL）中，M2 mMP的中值显着高度（1.46？×10 5 / ml）（p？= 027）。具有CRP或SAA的M1或M2 MMP没有显着的关联。结论与对照相比，含量较多的M2MMP在案例中是假设产生的。它可能代表患者易受ICH的慢性炎症状态的差异，例如细胞活化或细胞凋亡。需要进一步研究，包括连续血浆样品，以阐明单核细胞和MMP之后的单核细胞病理生理学。 ]]>

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