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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Combination of 24-Hour and 7-Day Relative Neurological Improvement Strongly Predicts 90-Day Functional Outcome of Endovascular Stroke Therapy
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Combination of 24-Hour and 7-Day Relative Neurological Improvement Strongly Predicts 90-Day Functional Outcome of Endovascular Stroke Therapy

机译：24小时和7天相对神经系统改善的组合强烈预测血管内卒中治疗的90天功能结果

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Background and Purpose: Early judgment of long-term prognosis is the key to making medical decisions in acute anterior circulation large-vessel occlusion stroke (LVOS) after endovascular treatment (EVT). We aimed to investigate the relationship between the combination of 24-hour and 7-day relative neurological improvement (RNI) and 90-day functional outcome. Methods: We selected the target population from a multicenter ischemic stroke registry. The National Institutes of Health Stroke Scale (NIHSS) scores at baseline, 24 hours, and 7 days were collected. RNI was calculated by the following equation: (baseline NIHSS -24-hour/7-day NIHSS)/baseline NIHSS x 100%. A modified Rankin Scale score of 0-2 at 90 days was defined as a favorable outcome. Multivariable logistic regression analysis was used to evaluate the relationship between RNI and 90-day outcome. Receiver operator characteristic curve analysis was performed to identify the predictive power and cutoff point of RNI for functional outcome. Findings: A total of 568 patients were enrolled. Both 24-hour and 7-day RNI were independent predictors of 90-day outcome. The best cutoff points of 24-hour and 7-day RNI were 28% and 42%, respectively. Compared with those with 24-hour RNI of less than 28% and 7-day RNI of less than 42%, patients with 24-hour RNI of 28% or greater and 7-day RNI of 42% or greater had a 39.595-fold (95% confidence interval 22.388-70.026)increased probability of achieving 90-day favorable outcome. Conclusions: The combination of 24-hour and 7-day RNI very strongly predicts 90-day functional outcome in patients with acute anterior circulation LVOS who received EVT, and it can be used as an early accurate surrogate of long-term outcome. (c) 2018 National Stroke Association. Published by Elsevier Inc. All rights reserved.
机译：背景论：早期判断长期预后是在血管内治疗后急性前循环大血管闭塞中风（LVOS）中的医学决策的关键（EVT）。我们旨在调查24小时和7天相对神经系统改善（RNI）和90天功能结果之间的关系。方法：我们从多中心缺血笔划注册表中选择了目标群体。收集了基线的国家卫生冲程量表（NIHSS）分数，24小时和7天。通过以下等式计算RNI :(基线NIHSS -24-小时/ 7天NIHSS）/基线NIHSS X 100％。 90天的修改Rankin比分为0-2的分数被定义为一个有利的结果。多变量逻辑回归分析用于评估RNI和90天结果之间的关系。进行接收器操作员特征曲线分析，以识别用于功能结果的RNI的预测力和截止点。调查结果：共有568名患者注册。 24小时和7天的RNI都是90天的独立预测因子。 24小时和7天RNI的最佳截止点分别为28％和42％。与24小时RNI少于28％和7天RNI的患者相比，患有28％或更大，7天RNI的24小时患者的42％或更大的患者具有39.595倍（95％置信区间22.388-70.026）提高了实现90天有利的结果的概率。结论：24小时和7天的组合非常强烈地预测患有EVT的急性前循环液患者90天的功能结果，可用作长期结果的早期准确的替代。 （c）2018国家冲程协会。由elsevier Inc.保留所有权利发布。

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    Pu Jie; Wang Huaiming; Tu Mingyi; Zi Wenjie; Hao Yonggang; Yang Dong; Liu Wenhua; Wan Yue; Geng Yu; Lin Min; Jin Ping; Xiong Yunyun; Xu Gelin; Yin Qin; Liu Xinfeng;

  • 作者单位

    Southern Med Univ Jinling Hosp Dept Neurol Nanjing Jiangsu Peoples R China;

    Nanjing Univ Jinling Hosp Dept Neurol Med Sch 305 East Zhongshan Rd Nanjing 210002 Jiangsu;

    Hubei Wuchang Hosp Dept Neurol Wuhan Hubei Peoples R China;

    Nanjing Univ Jinling Hosp Dept Neurol Med Sch 305 East Zhongshan Rd Nanjing 210002 Jiangsu;

    Southern Med Univ Jinling Hosp Dept Neurol Nanjing Jiangsu Peoples R China;

    Nanjing Univ Jinling Hosp Dept Neurol Med Sch 305 East Zhongshan Rd Nanjing 210002 Jiangsu;

    Wuhan 1 Hosp Dept Neurol Wuhan Hubei Peoples R China;

    Hubei Zhongshan Hosp Dept Neurol Wuhan Hubei Peoples R China;

    Hangzhou Med Coll Zhejiang Prov Peoples Hosp Peoples Hosp Dept Neurol Hangzhou Zhejiang;

    Peoples Liberat Army Dept Neurol Fuzhou Gen Hosp Fuzhou Fujian Peoples R China;

    Anhui Med Univ Dept Neurol Luan Affiliated Hosp Luan Anhui Peoples R China;

    Nanjing Univ Jinling Hosp Dept Neurol Med Sch 305 East Zhongshan Rd Nanjing 210002 Jiangsu;

    Nanjing Univ Jinling Hosp Dept Neurol Med Sch 305 East Zhongshan Rd Nanjing 210002 Jiangsu;

    Nanjing Univ Jinling Hosp Dept Neurol Med Sch 305 East Zhongshan Rd Nanjing 210002 Jiangsu;

    Southern Med Univ Jinling Hosp Dept Neurol Nanjing Jiangsu Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经病学与精神病学;
  • 关键词

    Stroke; relative neurological improvement; endovascular treatment; outcome;

    机译：中风;相对神经系统改善;血管内治疗;结果;

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