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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >The Accuracy of Serum Matrix Metalloproteinase-9 for Predicting Hemorrhagic Transformation After Acute Ischemic Stroke: A Systematic Review and Meta-Analysis
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The Accuracy of Serum Matrix Metalloproteinase-9 for Predicting Hemorrhagic Transformation After Acute Ischemic Stroke: A Systematic Review and Meta-Analysis

机译：血清基质金属蛋白酶-9预测急性缺血性中风后出血性转化的准确性：系统评价和荟萃分析

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Background: Hemorrhagic transformation is a serious complication of acute ischemic stroke, which may cause detrimental outcomes and the delayed use of anticoagulation therapy. Early predicting and identifying the patients at high risk of hemorrhagic transformation before clinical deterioration occurrence become a research priority. Objective: To study the value of plasma matrix metalloproteinase-9 predicting hemorrhagic transformation after ischemic stroke. Methods: We searched PubMed, Ovid, Cochrane Library, and other 2 Chinese databases to identify literatures published up to September 2017 and performed meta-analysis by STATA (version 12.0, StataCorp LP, College Station, TX). Results: Twelve studies incorporating 1492 participants were included and 7 studies were included in the quantitative statistical analysis. The pooled sensitivity was 85% (95% confidence interval [CI]: 75%, 91%) and the pooled specificity was 79% (95% CI: 67%, 87%). The area under the receiver operating characteristic curve was.89 (95% CI.86,.91). Significant heterogeneity for all estimates value existed (all the P value .05 and I-2 50%). There is no threshold effect with P value greater than .05 of the correlation coefficient. Meta-regression and subgroup analysis showed cut-off value and hemorrhagic subtype contributed to heterogeneity. Deeks' funnel plot indicated no significant publication bias for 7 quantitative analysis studies. Conclusions: Matrix metalloproteinase-9 has high predictive value for hemorrhagic transformation after acute ischemic stroke. It may be useful to test matrix metalloproteinase-9 to exclude patients at low risk of hemorrhage for precise treatment in the future clinical work.
机译：背景：出血性转化是急性缺血性卒中的严重并发症，这可能导致抗凝治疗的不利结果和延迟使用。早期预测和鉴定临床恶化发生前高风险转化风险的患者成为研究的优先权。目的：研究血浆基质金属蛋白酶-9预测缺血性中风后出血性转化的价值。方法：我们搜索了PubMed，Ovid，Cochrane图书馆和其他2个中文数据库，以识别2017年9月发布的文献，并通过Stata进行了Meta分析（第12.0版，Statacorp LP，学院，TX）。结果：含有1492名参与者的12项研究包括，7项研究包括在定量统计分析中。合并的敏感性为85％（95％置信区间[CI]：75％，91％）和汇集特异性为79％（95％CI：67％，87％）。接收器操作特征曲线下的区域为89（95％CI.86，.91）。存在所有估计值的显着异质性（所有p值<05和I-2＆ 50％）。 P值没有阈值效果大于相关系数的.05。荟萃回归和亚组分析显示截止值和出血性亚型，导致异质性。 Deeks'漏斗绘图表明7种定量分析研究没有显着的出版物偏差。结论：急性缺血性卒中后，基质金属蛋白酶-9对出血性转化具有高预测值。测试基质金属蛋白酶-9可能是有用的，以在未来的临床工作中以精确治疗的出血风险低的患者排除患者。

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