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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >The Association Between ACE2 Gene Polymorphism and the Stroke Recurrence in Chinese Population
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The Association Between ACE2 Gene Polymorphism and the Stroke Recurrence in Chinese Population

机译：ACE2基因多态性与中国人群中风复发的关联

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ObjectivesThe angiotensin-converting enzyme 2 (ACE2) is closely associated with cardiovascular disease and cerebrovascular disease. Most studies onACE2gene polymorphism focused on its relations with cardiovascular disease, but there was a lack of research on its relations with stroke. Our study aimed to explore the association between 4 single-nucleotidepolymorphisms (SNPs) ofACE2gene polymorphism and stroke recurrence. Design and ParticipantsIn our study, the case group included 125 stroke patients with recurrence and the control group included 153 patients without recurrence. Four SNPs (rs2106809, rs2285666, rs879922, and rs2074192) were genotyped by Ligase detection reaction. The association between stroke recurrence and SNPs were analyzed by multivariate logistic regression. ResultsWe find no association betweenACE2gene polymorphism and stroke recurrence. Haplotype A-G-C may associate with the stoke recurrence of male patients. The recurrence risk of male stroke patients with hypertension history and rs2285666-C allele is 2.82 times as high as that of those without hypertension history but with T allele. Among male stroke patients with hypertension history, the recurrence risk of those with rs2285666-C allele is 2.38 times as high as those with T allele; and the recurrence risk of those with rs2106809-A allele is 2.12 times as high as those with G allele. But those recurrence risks lose their statistical significance after adjustment for other factors. ConclusionsWe find no influence ofACE2gene polymorphism on stroke recurrence and only find possible interaction between hypertension history and theACE2gene in male stroke patients.
机译：客体血管紧张素转换酶2（ACE2）与心血管疾病和脑血管疾病密切相关。大多数研究有关2庚烯多态性的重点是其与心血管疾病的关系，但缺乏对其与中风的关系的研究。我们的研究旨在探讨4烯类多态性和中风复发的4个单核苷酸（SNP）之间的关联。我们的研究设计和参与者，案例组包括125名卒中患者复发，对照组包括153名没有复发的患者。四个SNP（RS2106809，RS2285666，RS879922和RS2074192）是通过连接酶检测反应进行基因分型。通过多变量逻辑回归分析中风复发和SNP之间的关联。结果在2庚烯多态性和中风复发之间没有关联。单倍型A-G-C可以与男性患者的粪便复发相关联。男性中风患者的高血压病史和RS2285666-C等位基因的复发风险比没有高血压病史的高度为2.82倍，但具有八等力。在具有高血压病史的男性中风患者中，RS2285666-C等位基因的复发风险与T等位基因有2.38倍;和RS2106809-A等位基因的复发风险是G等位基因的2.12倍。但这些复发风险在调整其他因素后失去了统计学意义。结论我们没有对卒中复发的影响毫无影响，并且仅在男性中风患者中发现高血压历史和特神2庚烯之间的可能相互作用。

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