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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >The JAGUAR Score Predicts 1-Month Disability/Death in Ischemic Stroke Patient Ineligible for Recanalization Therapy
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The JAGUAR Score Predicts 1-Month Disability/Death in Ischemic Stroke Patient Ineligible for Recanalization Therapy

机译：捷豹评分预测缺血性卒中患者的1个月残疾/死亡，没有资格再生治疗

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Background and PurposeMost available scoring system to predict outcome after acute ischemic stroke (AIS) were established in Western countries. We aimed to develop a simple prediction score of 1-month severe disability/death after onset in AIS patients ineligible for recanalization therapy based on readily and widely obtainable on-admission clinical, laboratory and radiological examinations in Asian developing countries. MethodsUsing the Shiga Stroke Registry, a large population-based registry in Japan, multivariable logistic regression analysis was conducted in 1617 AIS patients ineligible for recanalization therapy to yield ?-coefficients of significant predictors of 1-month modified Rankin Scale score of 5-6, which were then multiplied by a specific constant and rounded to nearest integer to develop 0-10 points system. Model discrimination and calibration were evaluated in the original and bootstrapped population. ResultsJapan Coma Scale score (J), age (A), random glucose (G), untimely onset-to-arrival time (U), atrial fibrillation (A), and preadmission dependency status according to the modified Rankin Scale score (R), were recognized as independent predictors of outcome. Each of their β-coefficients was multiplied by 1.3 creating the JAGUAR score. Its area under the curve (95% confidence interval) was .901 (.880- .922) and .901 (.900- .901) in the original and bootstrapped population, respectively. It was found to have good calibration in both study population (P= .27). ConclusionsThe JAGUAR score can be an important prediction tool of severe disability/death in AIS patients ineligible for recanalization therapy that can be applied on admission with no complicated calculation and multimodal neuroimaging necessary, thus suitable for Asian developing countries.
机译：在西方国家建立了背景技术以预测急性缺血性卒中（AIS）后预测结果的速度评分系统。我们的目标是在亚洲亚洲发展中国家的易于征收临床，实验室和放射学检查的遗传化治疗中，在AIS患者中发育1个月严重残疾/死亡的简单预测得分。 MethoMSUSUSINGS中，日本的大量基于人口的登记处，在1617名AIS患者中进行了多变量逻辑回归分析，其中不合适用于屈服治疗，以收益率为1个月的1个月改进的Rankin规模得分为5-6，然后将其乘以特定的常数并舍入到最接近的整数以开发0-10个点系统。在原始和引导的人口中评估了模型鉴别和校准。结果japan coma比分评分（j），年龄（a），随机葡萄糖（g），不合时宜的到达时间（U），根据修改的rankin规模得分（r） ，被认为是结果的独立预测因素。它们的每个β-系数乘以1.3创造了捷豹分数。其曲线下的区域（95％置信区间）分别为0.901（.880- .922）和.901（.900- .901），分别在原始和引导的人口中。在研究人群中发现它有良好的校准（P = .27）。结论捷豹评分可以是AIS患者的重要残疾/死亡的重要预测工具，无少少于重新调查治疗，可以在没有复杂的计算和必要的复杂计算和多模式神经影像中，因此适用于亚洲发展中国家。

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