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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Association between Cerebral Arterial Stiffness and Large Artery Atherosclerosis in Acute Ischemic Stroke
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Association between Cerebral Arterial Stiffness and Large Artery Atherosclerosis in Acute Ischemic Stroke

机译：急性缺血性卒中中脑动脉僵硬和大动脉动脉粥样硬化的关系

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Background and PurposeCarotid–cerebral pulse wave velocity (ccPWV) reflects the segment (C-M segment) stiffness between common carotid artery and ipsilateral middle cerebral artery. The C-M segment atherosclerosis (CMSA) is regarded as a most frequent cause of anterior circulation ischemic stroke. We therefore, attempted to investigate the relationship between cerebral arterial stiffness and CMSA, and provide reliable data for the early diagnosis of CMSA. MethodsBetween June 2012 and August 2016, 81 acute ischemic stroke (AIS) patients with 154 C-M segments successfully evaluated with digital subtraction angiography and ccPWV were enrolled into this study. Patient demographics and clinical data were retrieved from our AIS databases. ResultsMultivariate analyses showed that ccPWV was independently associated with CMSA (β?=?39.6,P?=?.009) and Systolic blood pressure (β?=?7.1,P< .001) in AIS patients. The values of ccPWV had a trend to be higher in the groups with more lesions (F?=?45.9,P< .01) and severer stenosis (F?=?102.6,P?=?.000), and was positively correlated with the number of lesions (r?=?.662,P?=?.000), and degree of stenosis (r?=?.858,P?=?.000) of CMSA. The fractional polynomial plots with 95% CIs also describe the close relationship between ccPWV and the number of lesions and degree of stenosis in CMSA. ConclusionsCerebral arterial stiffness is independently associated with the presence of CMSA, closely related to the vascular damage of C-M segment and reflects the vascular structure change of C-M segment in AIS patients. It may have the potential for assessment of CMSA in its initial stage.
机译：背景技术和三态胰岛素脉冲波速度（CCPWV）反映了常见的颈动脉和同侧中脑动脉之间的区段（C-M段）刚度。 C-M段动脉粥样硬化（CMSA）被认为是前循环缺血性卒中的最常见原因。因此，我们试图探讨脑动脉僵硬度和CMSA之间的关系，并提供可靠的CMSA早期诊断数据。二零一六月二零一二年六月和2016年8月，81例急性缺血性卒中（AIS）患有154个C-M段的患者，用数字减法血管造影和CCPWV成功评价了这项研究。从我们的AIS数据库中检索患者人口统计数据和临床数据。结果多变量分析表明，CCPWV与CMSA独立相关（β？= 39.6，P？=Δ.009）和AIS患者中的收缩压（β=β7.1，P <.001）。 CCPWV的值在具有更多病变的组中具有更高的趋势（f？= 45.9，p <.01）和严格的狭窄（f？= 102.6，p？=？000），并且是正相关的随着病变的数量（r？=Δ.662，p？=Δ000），并且狭窄程度（r？=Δ.。具有95％CIS的分数多项式图也描述了CCPWV与CMSA中损伤数和狭窄程度之间的密切关系。结论可与CMSA的存在独立相关，与C-M段的血管损伤密切相关，反映了AIS患者C-M段的血管结构变化。它可能有可能在其初始阶段评估CMSA。

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