...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Renal Dysfunction Associated with Symptomatic Intracranial Hemorrhage after Intravenous Thrombolysis
【24h】

Renal Dysfunction Associated with Symptomatic Intracranial Hemorrhage after Intravenous Thrombolysis

机译：肾功能障碍与静脉血栓溶解后患有症状颅内出血相关的肾功能障碍

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background and Aim: Renal dysfunction (RD) is prevalent in patients with acute ischemic stroke requiring intravenous thrombolysis. The relationship between renal function and thrombolysis related intracranial hemorrhagic (ICH) complications is contradictory according to previous studies. The current study is to clarify whether RD could increase the risk of symptomatic intracranial hemorrhage (SICH) after recombinant tissue plasminogen activator (IV rtPA) in acute ischemic stroke patients. Methods: In this observational study, acute ischemic stroke patients who received IV rtPA within 4.5 hours of symptom onset were retrospectively analyzed. Creatinine levels on admission served to calculate glomerular filtration rate (GFR) to estimate RD. SICH was defined with National Institute of Neurological Disorder and Stroke (NINDS, SICHNINDS) or European Cooperative Acute Stroke Study II (ECASS II, SICHECASSII) criteria. Association of RD with SICH was assessed using continuous GFR or binary GFR (RD defined as GFR < 90 ml/minute/1.73 m(2)). Results: Of 312 patients included, the incidence of SICHNINDS was 7.69%, of SICHECASSII was 5.45%. Patients with RD had higher prevalence of SICHNINDS (12.80% versus 2.03%, P < .001) and SICHECASS II (9.15% versus 1.35%, P = .002). GFR as a continuous variable was associated with SICHNINDS (ORadjust = .97, P = .003), but not with SICHECASS II. GFR less than 90 ml/minute/1.73 m2 remained independently associated with SICHNINDS (ORadjust = 4.79, P = .016), and SICHECASS II (ORadjust = 2.99, P = .032) in multiple logistic regression analysis. Conclusions: Renal function is independently associated with SICH after IV rtPA thrombolysis. RD is an independent predictor for both SICHNINDS and SICHECASS II. RD should be considered when evaluating the risk of intravenous thrombolysis with IV rtPA.
机译：背景和目的：急性缺血性卒中患者需要静脉溶栓患者肾功能紊乱（RD）普遍存在。肾功能与溶栓相关的颅内出血（ICH）并发症的关系是根据以前的研究矛盾。目前的研究是阐明Rd是否可以在急性缺血性卒中患者中重组组织纤溶酶原激活剂（IV RTPA）后症状颅内出血（SICH）的风险。方法：在这种观察性研究中，回顾性分析了症状发作4.5小时内接受IV RTPA的急性缺血性脑卒中患者。群体植物水平用于计算肾小球过滤速率（GFR）以估计RD。 Sich是用国家神经障碍和中风（Ninds，Sichninds）或欧洲合作急性中风研究II（ECASS II，Sichecassii）标准的标准。使用连续GFR或二元GFR评估RD与SICH的关联（RD定义为GFR <90ml /分钟/ 1.73 m（2））。结果：包括312名患者，Sichninds的发病率为7.69％，Sichecassii为5.45％。 RD患者的患者具有较高的Sichninds（12.80％对2.03％，P <.001）和SicheCass II（9.15％，与1.35％，P = .002）。作为连续变量的GFR与SichnInds（Oradjust = .97，P = .003）相关联，但不是SicheCass II。 GFR小于90毫升/分钟/ 1.73 M2仍然与SichnInds（Oradjust = 4.79，P = .016）和SicheCass II（Oradjust = 2.99，P = .032）独立关联。多逻辑回归分析。结论：IV RTPA溶栓后，肾功能与SICH独立相关。 RD是Sichninds和Sichecass II的独立预测因子。在评估IV RTPA静脉溶栓的风险时，应考虑RD。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号