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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Cerebral Blood Flow Response During Bolus Normal Saline Infusion After Ischemic Stroke
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Cerebral Blood Flow Response During Bolus Normal Saline Infusion After Ischemic Stroke

机译：在缺血性卒中后推注常生盐水输注过程中的脑血流反应

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Goals: We quantified cerebral blood flow response to a 500 cc bolus of 0.9%% normal saline (NS) within 96 hours of acute ischemic stroke (AIS) using diffuse correlation spectroscopy (DCS). Materials and Methods: Subjects with AIS in the anterior, middle, or posterior cerebral artery territory were enrolled within 96 hours of symptom onset. DCS measured relative cerebral blood flow (rCBF) in the bilateral frontal lobes for 15 minutes at rest (baseline), during a 30-minute infusion of 500 cc NS (bolus), and for 15 minutes after completion (post-bolus). Mean rCBF for each time period was calculated for individual subjects and median rCBF for the population was compared between time periods. Linear regression was used to evaluate for associations between rCBF and clinical features. Results: Among 57 subjects, median rCBF (IQR) increased relative to baseline in the ipsilesional hemisphere by 17% (-2.0%, 43.1%), P< 0.001, and in the contralesional hemisphere by 13.3% (-4.3%, 36.0%), P < .004. No significant associations were found between ipsilesional changes in rCBF and age, race, infarct size, infarct location, presence of large vessel stenosis, NIH stroke scale, or symptom duration. Conclusion: A 500 cc bolus of .9% NS produced a measurable increase in rCBF in both the affected and nonaffected hemispheres. Clinical features did not predict rCBF response.
机译：目标：使用漫反射谱（DCS）在96小时内定量脑血流响应于0.9 %%盐水（NS）的500cc吐烟剂。材料和方法：在症状发作的96小时内纳入前，中间，后脑动脉区域的AIS受试者。 DCS在双侧前叶中测量相对脑血流量（RCBF）在静止（基线），在500cc NS（推注）的30分钟内，在完成后15分钟（后推注）。对于各个时间段的平均RCBF为各个受试者计算，并且在时间段之间比较了人口中位数的RCBF。线性回归用于评估RCBF与临床特征之间的关联。结果：57个受试者中，中位数RCBF（IQR）相对于IPsilesional Hemisphere中的基线增加17％（-2.0％，43.1％），p <0.001，并且在对立半球中，达到13.3％（-4.3％，36.0％ ），p <.004。在RCBF和年龄，竞争，梗塞大小，梗塞位置，大容器狭窄，NIH中风尺度或症状持续时间的情况下，无明显的关联。结论：500cc Zolus，0.9％NS在受影响和非受影响的半球中产生了RCBF的可测量增加。临床特征未预测RCBF响应。

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