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首页> 外文期刊>Journal of the Academy of Nutrition and Dietetics >Dietary Long-Chain n-3 Fatty Acid Intake and Arthritis Risk in the Women’s Health Initiative
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Dietary Long-Chain n-3 Fatty Acid Intake and Arthritis Risk in the Women’s Health Initiative

机译：膳食长链N-3脂肪酸摄入量和关节炎风险在妇女的健康倡议中

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BackgroundThe prevalence of arthritis in the United States is substantial and on the rise. Long-chain n-3 polyunsaturated fatty acids, which have anti-inflammatory properties, have been shown to provide therapeutic benefit to arthritis patients; however, to date few have examined these associations with arthritis risk.ObjectiveThe study objective was to examine the associations of long-chain n-3 polyunsaturated fatty acids intake with osteoarthritis (OA) and rheumatoid arthritis (RA) risk among postmenopausal women.DesignThis was a prospective cohort study.ParticipantsThe sample for this analysis consisted of 80,551 postmenopausal women, aged 55 to 79 years and with no history of arthritis, recruited into the Women’s Health Initiative Observational Study and Clinical Trials cohort between 1993 and 1998. Women completed a 120-item food frequency questionnaire at baseline.Main outcome measuresAfter a median follow-up of 8 years, 22,306 incident OA and 3,348 RA cases were identified.Statistical analyses performedAdjusted Cox regression models were used to estimate hazard ratios and 95% CI for the associations between dietary LCn-3PUFA intake and OA and RA risk.ResultsIndividual and total long-chain n-3 polyunsaturated fatty acids (Quintile 5 vs Quintile 1: hazard ratio 1.04, 95% CI 0.99 to 1.09 for OA; hazard ratio 1.01, 95% CI 0.90 to 1.13 for RA) were not associated with OA and RA risk. Further, no associations were observed between n-6 polyunsaturated fatty acids intake and either arthritis outcome.ConclusionsThis study is the first to examine associations of long-chain n-3 polyunsaturated fatty acids intake with OA risk and the largest to examine associations with RA risk. Despite their therapeutic potential, the study provides no evidence of benefit of these nutrients in relation to arthritis risk.
机译：背景，美国关节炎的患病率是大幅的，崛起。已显示具有抗炎特性的长链N-3多不饱和脂肪酸，用于为关节炎患者提供治疗益处;然而，迄今为止，迄今为止已经研究了与关节炎风险的关联。毒物研究目的是检查长链N-3多不饱和脂肪酸摄入量与骨关节炎（OA）和类黄酮关节炎（RA）风险的关联性研究目的是核心产业妇女之间的核心关节炎（RA）风险.Designthis是一个未来的队列研究。该分析的氨基吡啶氏素样品由80,551名绝经后妇女组成，55至79岁，没有关节炎史，招募到1993年至1998年间妇女的健康倡议观察研究和临床试验队列。妇女完成了120-项目食品频率调查问卷.Main成果措施中的8岁的中位随访，确定了22,306份事件OA和3,348例案件。统计分析用于估算饮食之间的危险比和95％CI的危险比率和95％CI。 LCN-3PUFA摄入量和OA和RA风险。方法，但总分枝和总长链N-3多不饱和脂肪酸（五分5 VS五分之一：危险比1.04,95％CI 0.99至1.09为OA;危险比1.01,801,801，Ra的95％CI 0.90至1.13与OA和RA风险无关。此外，在N-6多不饱和脂肪酸摄入和关节炎结果之间没有观察到任何关联。结论性研究是第一个研究长链N-3多不饱和脂肪酸的关联与OA风险和最大的患者审查与RA风险的关联。尽管他们治疗潜力，但该研究没有提供与关节炎风险有关这些营养素的有益的证据。

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