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首页> 外文期刊>Journal of the American Pharmacists Association: JAPhA >Lofexidine versus clonidine for mitigation of opioid withdrawal symptoms: A systematic review
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Lofexidine versus clonidine for mitigation of opioid withdrawal symptoms: A systematic review

机译:Lofexidine与Clonidine减轻阿片类药物戒断症状:系统审查

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摘要

Objectives: The U.S. Food and Drug Administration recently approved lofexidine, an alpha-2-adrenergic agonist, as the first non-opioid medication for mitigation of opioid withdrawal symptoms. Clonidine, an alpha-2-adrenergic agonist, historically was used off-label for this indication. This review aimed to evaluate the effectiveness of lofexidine versus clonidine for mitigation of opioid withdrawal symptoms and to discuss the current role of lofexidine in the management of patients at risk of experiencing opioid withdrawal.
机译:目的:美国食品和药物管理局最近批准了Lofexidine,一种α-2-肾上腺素能激动剂,作为第一个用于减轻阿片类药物戒断症状的非阿片类药物。 Clonidine,α-2-肾上腺素能激动剂,历史上用于此指示的标签。 该审查旨在评估洛菲塞赖丁与克隆酮的有效性,以减轻阿片类药物戒断症状,并探讨Lofexidine在体验阿片类药物戒断的患者管理中的当前作用。

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