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首页> 外文期刊>Journal of pharmacy practice >Drug-Induced Vitamin B_(12) Deficiency: A Focus on Proton Pump Inhibitors and Histamine-2 Antagonists
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Drug-Induced Vitamin B_(12) Deficiency: A Focus on Proton Pump Inhibitors and Histamine-2 Antagonists

机译：药物诱导的维生素B_（12）缺乏：专注于质子泵抑制剂和组胺-2拮抗剂

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Objective: To review primary literature of gastric acid suppressive agents and vitamin B_(12) deficiency. Data Synthesis: From the published articles, proton pump inhibitors (PPIs) are associated with a higher risk of inducing vitamin B_(12) deficiency than histamine-2 receptor antagonists (H2RAs). Literature suggests that there is an increased risk of developing vitamin B_(12) deficiency in patients who are exposed to extended durations of therapy with PPIs. There are, however, some conflicting data in elderly patients suggesting that the PPI use for more than 3 years does not increase the risk of vitamin B_(12) deficiency. No evidence was found to support the extended use of H2RA monotherapy causing vitamin B_(12) deficiency. The inconsistency of results reported could be due to the differing patient populations studied, such as Zollinger-Ellison syndrome (ZES) and elderly patients. Overall, the lack of consistent evidence shows the need for more research in this area. Conclusion: To investigate the clinical significance of vitamin B_(12) deficiency caused by acid suppression with PPIs and H2RAs, longer prospective studies are needed. These studies should focus on patient-centered outcomes to accurately determine the extended usage of PPI and H2RA and the true effects on vitamin B_(12) deficiency.
机译：目的：审查胃酸抑制剂和维生素B_（12）缺乏的主要文献。数据合成：来自已发表的制品，质子泵抑制剂（PPI）与诱导维生素B_（12）缺乏的风险较高，所述维生素B_（12）缺乏多于组胺-2受体拮抗剂（H2RAS）。文献表明，在用PPI的延长治疗延长持续治疗的患者中发育维生素B_（12）缺乏的风险增加。然而，在老年患者中存在一些矛盾的数据，表明PPI使用超过3年不会增加维生素B_（12）缺乏的风险。没有发现证据支持H2RA单药治疗的扩展使用，导致维生素B_（12）缺乏症。报告的结果不一致可能是由于所研究的患者人群，如Zollinger-ellison综合征（Zes）和老年患者。总体而言，缺乏一致的证据表明，需要在该地区进行更多研究。结论：探讨维生素B_（12）用PPI和H2RAS引起的维生素B_（12）缺乏症的临床意义，需要更长的前瞻性研究。这些研究应专注于患者中心结果，以准确确定PPI和H2RA的扩展使用以及对维生素B_（12）缺乏的真正影响。

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