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首页> 外文期刊>Alimentary pharmacology & therapeutics. >Scoring systems for 6-month mortality in critically ill cirrhotic patients: A prospective analysis of chronic liver failure - Sequential organ failure assessment score (CLIF-SOFA)
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Scoring systems for 6-month mortality in critically ill cirrhotic patients: A prospective analysis of chronic liver failure - Sequential organ failure assessment score (CLIF-SOFA)

机译：重症肝硬化患者6个月死亡率评分系统：慢性肝衰竭的前瞻性分析-器官功能衰竭评估评分（CLIF-SOFA）

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Background Cirrhotic patients admitted to intensive care units (ICUs) have high mortality rates. The Chronic Liver Failure-Sequential Organ Failure Assessment (CLIFSOFA) score, a modified Sequential Organ Failure Assessment (SOFA) score, is a newly developed scoring system exclusively for patients with end-stage liver disease.Aim To externally validate the efficacy of the CLIF-SOFA score and evaluate other scoring systems for 6-month mortality in critically ill cirrhotic patients.Methods This study prospectively recorded and analysed the data for 30 demographical parameters and some clinical characteristic variables on day 1 of 250 cirrhotic patients admitted to a 10-bed specialised hepatogastroenterology ICU in a 2000-bed tertiary care referral hospital during the period from September 2010 to August 2013.Results The overall in-hospital and 6-month mortality rate were 58.8% (147/250) and 78.0% (195/250), respectively. Liver diseases were mostly attributed to hepatitis B virus infection (32%). Multiple Cox logistic regression hazard analysis revealed that Glasgow coma scale, both the CLIF-SOFA and Acute Physiology and Chronic Health Evaluation III (ACPACHE III) scores determined on the first day of ICU admission were independent predictors of 6-month mortality. Analysis of the area under the receiver operating characteristic curve revealed that the CLIF-SOFA score had the best discriminatory power (0.900 ± 0.020). Moreover, the cumulative 6-month survival rates differed significantly for patients with a CLIF-SOFA score ≤11 and those with a CLIF-SOFA score >11 on the ICU admission day.Conclusion Both CLIF-SOFA and APACHE III scores are excellent prognosis evaluation tools for critically ill cirrhotic patients.
机译：背景技术重症监护病房（ICU）入院的肝硬化患者死亡率很高。慢性肝功能衰竭-序贯器官衰竭评估（CLIFSOFA）评分是一种改良的序列性器官衰竭评估（SOFA）评分，是专门针对晚期肝病患者的一种新开发的评分系统。目的在外部验证CLIF的有效性-SOFA评分并评估其他重度肝硬化患者6个月死亡率的评分系统。方法前瞻性记录和分析250例10张病床的肝硬化患者在第1天的30个人口统计学参数和一些临床特征变量的数据在2010年9月至2013年8月期间，在2000张病床的三级转诊医院进行了专门的肝肠胃病ICU。结果总体住院和6个月死亡率分别为58.8％（147/250）和78.0％（195/250） ， 分别。肝病主要归因于乙型肝炎病毒感染（32％）。多重Cox logistic回归风险分析显示，ICU入院第一天确定的格拉斯哥昏迷量表，CLIF-SOFA和急性生理学和慢性健康评估III（ACPACHE III）评分是6个月死亡率的独立预测因子。对接收器工作特性曲线下面积的分析表明，CLIF-SOFA得分具有最佳区分能力（0.900±0.020）。而且，在入院当天，CLIF-SOFA评分≤11的患者和CLIF-SOFA评分> 11的患者的6个月累积生存率差异显着。结论CLIF-SOFA和APACHE III评分均是良好的预后评估重症肝硬化患者的工具。

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