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首页> 外文期刊>Journal of the American Academy of Child and Adolescent Psychiatry >Reduced error-related activation of dorsolateral prefrontal cortex across pediatric anxiety disorders
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Reduced error-related activation of dorsolateral prefrontal cortex across pediatric anxiety disorders

机译：对小儿焦虑症的误差相关激活误差激活背侧前额甲皮质

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Objective Abnormalities of cognitive control functions, such as conflict and error monitoring, have been theorized to underlie obsessive-compulsive symptoms but only recently have been considered a potentially relevant psychological construct for understanding other forms of anxiety. The authors sought to determine whether these cognitive control processes elicit the same abnormalities of brain function in patients with pediatric obsessive-compulsive disorder (OCD) as in those with non-OCD anxiety disorders. Method Functional magnetic resonance imaging of the Multisource Interference Task was used to measure conflict- and error-related activations in youth (8-18 years) with OCD (n = 21) and non-OCD anxiety disorders (generalized anxiety disorder, social phobia, separation anxiety disorder; n = 23) compared with age-matched healthy controls (n = 25). Results There were no differences in performance (accuracy, response times) among groups. However, a significant effect of group was observed in the dorsolateral prefrontal cortex (dlPFC) during error processing, driven by decreased activation in patients with OCD and those with non-OCD anxiety compared with healthy youth. Between patient groups, there was no difference in error-related dlPFC activation. Conclusions Hypoactive dlPFC response to errors occurs in pediatric patients with OCD and those with non-OCD anxiety. These findings suggest that insufficient error-related engagement of the dlPFC associates with anxiety across traditional diagnostic boundaries and appears during the early stages of illness.
机译：认知控制功能的客观异常，如冲突和错误监测，已经理论为强迫症状而受到理论化，但最近仅被认为是理解其他形式的焦虑的潜在相关的心理构建。作者试图确定这些认知控制过程是否引起儿科强迫症（OCD）的患者中脑功能的相同异常，如非洲焦虑症的那些。方法使用多源干扰任务的功能磁共振成像用于测量青少年（8-18岁）的冲突和错误相关的激活，OCD（n = 21）和非洲焦虑症（广义焦虑症，社会恐怖症，分离焦虑症; n = 23）与年龄匹配的健康对照相比（n = 25）。结果组中的性能（准确性，响应时间）没有差异。然而，在误差处理期间在误差处理中观察到基团的显着效果，通过COCD患者的活化降低和与健康青年相比具有非强迫性焦虑的激活来驱动。在患者组之间，错误相关的DLPFC激活没有差异。结论对具有非强迫症患者的儿科患者和非强迫性焦虑的人发生过吸的DLPFC对误差的反应。这些调查结果表明，DLPFC伴随着传统诊断界限的焦虑与焦虑的错误相关的判决何种判断，并且在疾病的早期阶段出现。

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