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首页> 外文期刊>Journal of science and medicine in sport >An association between polymorphisms within the APOE gene and concussion aetiology in rugby union players
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An association between polymorphisms within the APOE gene and concussion aetiology in rugby union players

机译：在橄榄球联盟球员中ApoE基因和震荡抑制剂中多态性的关联

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Abstract Objectives Concussion refers to changes in neurological function due to biomechanical forces transmitted to the head. The APOE ε4 allele is associated with brain injury severity. The objective was to determine if APOE gene variants are associated with concussion history and severity in rugby players. Design In total, 128 non-concussed controls and 160 previously concussed participants (all cases N=160; diagnosed N=139) were recruited from high school (junior, N=121), club (N=116) and professional rugby teams (N=51). Methods Participants were genotyped for rs405509 (G>T), rs429358 (T>C) and rs7412 (C>T) APOE variants. Statistical analyses were performed using the R environment. Results The rs405509 TT genotype was over-represented in controls compared to all cases ( P =0.043; control: 29%, all cases: 18%; odds ratio: 0.55, 95% confidence interval 0.31–0.98). The APOE -ε isoform frequencies were not significantly different between groups ( P > 0.05). Additionally, the inferred APOE (rs405509-ε2/ε3/ε4) T-ε3 haplotype was over-represented in controls (41%) compared to diagnosed (32%, P =0.042). The G-ε3 haplotype was under-represented in controls (36%) compared to all cases (44%, P =0.019) and diagnosed (44%, P =0.021). The TT genotype was significantly associated with rapid recovery ( P =0.048, Conclusions These findings support the further elucidation of the APOE gene or closely-related genes in concussion aetiology. Although similar preliminary results were found when juniors were separately analysed, the under-powered sample size for junior subgroup requires future investigation in larger cohorts of junior-level athletes.
机译：摘要目标震荡是指由于生物力学传递到头部的神经功能的变化。 Apoeε4等位基因与脑损伤严重程度有关。目的是确定ApoE基因变异是否与橄榄球运动员的脑震荡历史和严重程度相关。从高中（初级，N = 121），俱乐部（N = 116）和专业橄榄球队（N = 116）和专业的橄榄球队（N = 116）和专业的橄榄球队（ n = 51）。方法参与者对RS405509（G> T），RS429358（T> C）和RS7412（C> T）ApoE变体进行基因分型。使用R环境进行统计分析。结果与所有情况相比，对照组rs405509 TT基因型（P = 0.043;控制：29％，所有情况：18％;差距：0.55,95％置信区间0.31-0.98）。 APOE-ε同种型频率在组之间没有显着差异（P> 0.05）。另外，与诊断术（32％，P = 0.042）相比，将推断的apoE（RS405509-ε2/ε3/ε3/ε3）T-ε3单倍型以对照（41％）过度表示。与所有病例相比（44％，P = 0.019）和诊断（44％，P = 0.021）相比，G-ε3单倍型在对照（36％）下面表示（36％）。 TT基因型与快速恢复显着相关（P = 0.048，结论这些发现支持肠道抑制中的ApoE基因或密切相关基因的进一步阐明。虽然当小学分别分别分析时，虽然发现了类似的初步结果，但是当前的初步结果初级小组的样本大小需要在初级运动员的较大队列中进行未来调查。

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