...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of the Iranian Chemical Society >Double injection-single detector flow injection spectrophotometric method for simultaneous determination of ascorbic acid and paracetamol in pharmaceutical formulations
【24h】

Double injection-single detector flow injection spectrophotometric method for simultaneous determination of ascorbic acid and paracetamol in pharmaceutical formulations

机译：双注射单检测器流动注射分光光度法，用于同时测定药物制剂中抗坏血酸和扑热氨基酚

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A simple and low-cost flow injection spectrophotometric method was proposed for the simultaneous determination of ascorbic acid (AA) and paracetamol (PCM) in pharmaceutical formulations. The present method is based on the reduction of Fe(III) to Fe(II) with AA and PCM in a closed flow system which subsequently combines with the 1,10-phenanthroline to form an orange-coloured complex that is measured at 510 nm. The increase in the absorbance was proportional to the concentration of AA in the range of 0.1-12 mu g/ml with a correlation coefficient of 0.9997 and detection limit of 0.31 mu g/ml, and to the concentration of PCM in the range of 0.4-24 mu g/ml with a correlation coefficient of 0.9999 and detection limit of 0.39 mu g/ml. The precision for ten serial estimations of 2 and 7 mu g/ml of AA exhibited a relative standard deviation of 3.33% and 2.47% and of 6 and 15 mu g/ml of PCM with a relative standard deviation of 3.008% and 2.23%, respectively. The present FI method permits determination of 9 samples per hour with no interference from the common excipients. The developed method was applied to different tablets containing AA and PCM with the recovery of AA from four spiked samples ranged from 95.31 to 104.73%, and of PCM ranged from 95.03 to 104.93%.
机译：提出了一种简单而低成本的流动分光光度法，用于同时测定药物制剂中的抗坏血酸（AA）和扑热氨基酚（PCM）。本方法基于在闭合流动系统中使用AA和PCM的Fe（III）至Fe（II）的减少，其随后与1,10-菲咯啉结合以形成在510nm处测量的橙色复合物。吸光度的增加与0.1-12μg/ ml的浓度成比例，其相关系数为0.9997，检测极限为0.31μg/ ml，并且PCM的浓度在0.4的范围内-24μg/ ml，相关系数为0.9999，检测限为0.39μg/ ml。用于2和7μg/ ml AA的10个串联估计的精度表现出3.33％和2.47％和6和15μg/ ml的PCM的相对标准偏差，相对标准偏差为3.008％和2.23％，分别。本发明的方法允许确定每小时9个样品，没有来自普通赋形剂的干扰。将开发方法应用于含有AA和PCM的不同片剂，其来自四个尖刺样品的AA，范围为95.31至104.73％，PCM的范围为95.03至104.93％。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号