Microwave-induced one-pot synthesis of pyrimidine-2(1H)-one derivatives as anti-inflammatory agents

Sahoo Biswa Mohan; Banik Bimal Krishna; Mahato Arun Kumar

首页> 外文期刊>Journal of the Indian Chemical Society >Microwave-induced one-pot synthesis of pyrimidine-2(1H)-one derivatives as anti-inflammatory agents

【24h】

Microwave-induced one-pot synthesis of pyrimidine-2(1H)-one derivatives as anti-inflammatory agents

机译：微波诱导的嘧啶-2（1H） - 衍生物作为抗炎剂的单罐合成

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

A series of pyrimidine-2(1H)-one derivative were obtained by multi-component one-pot synthesis under microwave irradiation. Equimolar quantities of ethylacetoacetate, substituted benzaldehydes and urea undergo condensation, followed by cyclizaton in presence of aqueous solution of sodium hydroxide to produce corresponding pyrimidine derivatives. With the help of microwave heating, there is clean reaction with shorter reaction time, environmental-friendly, improved yield as compared to conventional heating method. The structures of the newly synthesized compounds have been established on the basis of their IR, NMR spectral data. These compounds were screened for their anti-inflammatory activity. Some of them were found to possess significant activity as compared to standard drug.

机译：通过微波辐射下的多组分单盆合成获得一系列嘧啶-2（1H）衍生物。等摩尔数量的乙基乙酸酯，取代的苯甲醛和尿素经历缩合，然后在氢氧化钠水溶液存在下进行水合物，以产生相应的嘧啶衍生物。借助微波加热，与传统加热方法相比，较短的反应时间，环境友好，产率更高的含水反应。已经基于其IR，NMR光谱数据建立了新合成的化合物的结构。将这些化合物筛选出抗炎活性。与标准药物相比，他们中的一些人被发现具有显着的活动。

著录项

来源
《Journal of the Indian Chemical Society》 |2018年第11期|共5页
作者
Sahoo Biswa Mohan; Banik Bimal Krishna; Mahato Arun Kumar;
展开▼
作者单位

Vikas Grp Inst Dept Pharm Vijayawada Rural 521212 Andhra Pradesh India;

Community Hlth Syst South Texas Edinburg TX 78539 USA;

Sardar Bhagwan Singh Univ Dept Pharmaceut Sci Dehra Dun 248161 Uttarakhand India;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类化学;
关键词
Microwave; synthesis; pyrimidine; anti-inflammatory agents; spectral data;

机译：微波;合成;嘧啶;抗炎剂;光谱数据;

相似文献

外文文献
中文文献
专利

1. Microwave-induced one-pot synthesis of pyrimidine-2(1H)-one derivatives as anti-inflammatory agents [J] . Sahoo Biswa Mohan, Banik Bimal Krishna, Mahato Arun Kumar Journal of the Indian Chemical Society . 2018,第11期

机译：微波诱导的嘧啶-2（1H） - 衍生物作为抗炎剂的单罐合成
2. Diastereoselective and Efficient Synthesis of Indeno[2 '',1 '':4 ',5 ']furo[3 ',2 ':5,6]pyrido[2,3-d]pyrimidine-2,4,6(1H,3H)-trione and 6-(2,3-Dihydro-2-hydroxy-1,3-dioxo-1H-inden-2-yl)-5,8-dihydropyrido[2,3-d]pyrimidine-2,4,7(1H,3H,6H)-trione Derivatives [J] . Saberi Dariush, Mohammadizadeh Mohammad Reza, Esmaeili Reza Helvetica chimica acta . 2015,第10期

机译：Indeno [2''，1''：4'，5']呋喃[3'，2'：5,6]吡啶并[2,3-d]嘧啶-2,4,6（1H）的非对映选择性合成，3H）-三酮和6-（2,3-二氢-2-羟基-1,3-二氧代-1H-茚满-2-基）-5,8-二氢吡啶并[2,3-d]嘧啶-2， 4,7（1H，3H，6H）-三酮衍生物
3. MICROWAVE-INDUCED ONE-POT SYNTHESIS OF SOME NEW SPIRO [INDOLINE-3,2'-THIAZOLIDINE]-2,4'-(1H)-DIONES AND BIS[SPIRO[INDOLINE-3,2'-THEAZOLIDINE]-2,4'-(1H)-DIONES] [J] . Azizian Javad Synthetic Communications . 2000,第3期

机译：微波诱导的一些新螺环[INDOLINE-3,2'-噻唑啉] -2,4'-（1H）-二酮和BIS [SPIRO [INDOLINE-3,2'-THEAZOLIDINE] -2,4 '-（（1H）-DIONES]
4. Glassy 2-(1-benzyl-2-styryl-6-methylpyridin-4(1-H)-ylidene) fragment containing 1H-indene-1,3(2H)-dione and pyrimidine-2,4,6(1H,3H,5H)-trione derivatives with light-emitting and amplified spontaneous emission properties [C] . Elmars Zarins, Julija Pervenecka, Elina Misina, Conference on Fiber Lasers and Glass Photonics: Materials through Applications . 2020

机译：含1H-茚-1,3（2H）-二酮和嘧啶-2,4,6（1H）的玻璃状2-（1-苄基-2-苯乙烯基-6-甲基吡啶-4（1-H）-亚烷基）片段具有发光和放大的自发发射特性的3H，5H）-三酮衍生物
5. New developments toward the synthesis of heterocycles and applications in green chemistry. I. A simple and essentially one-pot synthesis of N-aminated heterocycles using phase transfer catalyst (Aliquat-336). II. Synthesis of pharmaceutically important pyrrole derivatives. III. Applications in green chemistry: Surfactant-mediated environmentally friendly cleavage of aromatic esters and trans-esterification under solvent-free neutral conditions . [D] . Patel, Nitinchandra. 2005

机译：杂环合成的新进展及其在绿色化学中的应用。 I.使用相转移催化剂（Aliquat-336）简单且基本上一锅合成N-胺化的杂环。二。药学上重要的吡咯衍生物的合成。三，在绿色化学中的应用：在无溶剂的中性条件下，表面活性剂介导的环境友好的芳族酯裂解和酯交换反应。
6. One-Pot Multicomponent Synthesis and Bioevaluation of Tetrahydroquinoline Derivatives as Potential Antioxidants α-Amylase Enzyme Inhibitors Anti-Cancerous and Anti-Inflammatory Agents [O] . Samra Farooq, Aqsa Mazhar, Areej Ghouri, 2020

机译：一锅多组分合成四氢喹啉衍生物作为潜在的抗氧化剂α-淀粉酶抑制剂抗癌和抗炎剂的生物评价
7. Mechanochemical Solvent-Free and Catalyst-Free One-Pot Synthesis of Pyrano[2,3-d]Pyrimidine-2,4(1H,3H)-Diones with Quantitative Yields [O] . M. Reza Naimi-Jamal, Sara Mashkouri 2009

机译：机械化学无溶剂和无催化剂一锅法合成具有定量产率的吡喃并[2,3-d]嘧啶-2,4（1H，3H） - 二酮

Microwave-induced one-pot synthesis of pyrimidine-2(1H)-one derivatives as anti-inflammatory agents

摘要

著录项

相似文献

相关主题

期刊订阅