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首页> 外文期刊>Journal of the Indian Chemical Society >Microwave-assisted synthesis and evaluation of indole derivatives as potential anthelmintic agents
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Microwave-assisted synthesis and evaluation of indole derivatives as potential anthelmintic agents

机译：微波辅助合成和评价吲哚衍生物作为潜在的构型药剂

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An efficient method is developed and exploited for the synthesis of indole derivatives via microwave-assisted technology. By considering the advantage microwave synthesis in terms of high efficient energy, indole derivatives are prepared. In the current study, the Schiff's bases are first synthesized by reaction of 1H-indole-2,3-dione (isatin) with various substituted anilines in presence of acetic acid under microwave irradiation. Then the Mannich bases are produced by condensation of Schiff bases with different secondary amines in the presence of formaldehyde. The newly synthesized compounds are characterized by TLC report and spectral data followed by evaluation for anthelmintic activity against Pheretima posthuma. Albendazole is used as standard drug for comparative study. The titled compounds are screened for anthelmintic activity at the concentration of 10, 20 and 50 mg/ml. The anthelmintic effect of standard drug Albendazole is also evaluated at 10 mg/ml. The results of present study indicate that some of the tested compounds exhibit significant anthelmintic activity in dose dependent manner.
机译：通过微波辅助技术开发和利用有效的方法来合成吲哚衍生物。通过考虑在高效能量方面的优势微波合成，制备吲哚衍生物。在目前的研究中，首先通过在微波辐射下在乙酸存在下具有各种取代的苯胺的1H-吲哚-2,3-二酮（Isatin）来合成Schiff的碱。然后曼尼奇碱是通过在甲醛存在下用不同仲胺的Schiff碱的冷凝产生的。新合成的化合物的特征在于TLC报告和光谱数据，然后评估针对Pheretima Posthuma的弓形活动。 Albendazole用作比较研究的标准药物。将标题的化合物筛选在浓度为10,20和50mg / ml的浓度下进行抗牙本质活性。标准药物阿苯唑的触发效果也在10mg / ml下评估。本研究结果表明，一些测试化合物以剂量依赖性方式表现出显着的化学活性。

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