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首页> 外文期刊>Journal of vestibular research: equilibrium and orientation >Vestibular adaptation studied with a prosthetic semicircular canal.
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Vestibular adaptation studied with a prosthetic semicircular canal.

机译：前庭适应研究了假肢半圆形管。

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摘要

We have developed and tested a prosthetic semicircular canal that senses angular head velocity and uses this information to modulate the rate of current pulses applied to the vestibular nerve via a stimulating electrode. In one squirrel monkey, the lateral canals were plugged bilaterally and the prosthesis was secured to the animal's head with the angular velocity sensor parallel to the axis of the lateral canals. In the first experiment, the stimulating electrode was placed near the ampullary nerve of one lateral canal. Over a period of two weeks, the gain of the horizontal VOR during yaw axis rotation gradually increased, although the response magnitude remained relatively small. In the second experiment, the stimulating electrode was placed near the ampullary nerve of the posterior canal, but the orientation of the velocity sensor remained parallel to the axis of the lateral canals. Over a one-week period, the axis of the VOR response gradually shifted towards alignment with the (yaw) axis of head rotation. Chronic patterned stimulation of the eighth nerve can therefore provide adequate information to the brain to generate a measurable VOR response, and this can occur even if the prosthetic yaw rotation cue is provided via a branch of the VIIIth nerve that doesn't normally carry yaw rotational cues. The results provided by this pilot study suggest that it may be feasible to study central adaptation by chronically modifying the afferent vestibular cue with a prosthetic semicircular canal.
机译：我们已经开发并测试了一个假肢半圆形管，其感测角头速度，并使用该信息通过刺激电极调节施加到前庭神经的电流脉冲速率。在一个松鼠猴中，双侧堵塞横向管，并且假体用平行于侧管的轴线的角速度传感器固定到动物的头部。在第一实验中，将刺激电极置于一个侧向管的枕腔附近。在两周的时间内，横摆轴旋转期间水平vor的增益逐渐增加，尽管响应幅度仍然相对较小。在第二种实验中，将刺激电极放置在后部管道的枕腔神经附近，但速度传感器的取向保持平行于横向管的轴线。在一周的时间内，VOR响应的轴逐渐朝向与（横摆）的头旋转轴的对准。因此，第八神经的慢性图案化刺激可以向大脑提供足够的信息以产生可测量的VOR响应，并且即使通过VIIITH神经的分支提供假肢偏航旋转提示，这也可以发生这种假肢旋转线，这通常不会旋转偏航提示。该试点研究提供的结果表明，通过按时间用假肢管道进行长期修饰传入前庭提示，研究中央适应可能是可行的。

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