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首页> 外文期刊>Journal of veterinary cardiology >NT-proBNP, NT-proANP and cTni concentrations in dogs with pre-capillary pulmonary hypertension.
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NT-proBNP, NT-proANP and cTni concentrations in dogs with pre-capillary pulmonary hypertension.

机译：具有毛细血管前肺动脉高压的狗的NT-ProPNP，NT-ProAnp和CTNI浓度。

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Objectives: To compare [NT-proBNP], [NT-proANP] and [cTnI] between control dogs with respiratory disease without pulmonary hypertension (PH) and dogs with pre-capillary PH, and to assess the accuracy of [NT-proBNP], [NT-proANP], [cTnI] to predict Doppler-derived peak tricuspid regurgitation (TR) gradient. Animals: 20 dogs. 8 control dogs with respiratory disease with no PH and 12 with pre-capillary PH. Methods: [NT-proBNP], [NT-proANP] and [cTnI] were compared between the 2 groups and simple linear regression analysis was used to predict peak TR gradients from various blood biomarkers. Results: Median [NT-proBNP] was higher in the dogs with PH (2011 pmol/L, 274-7713 pmol/L) compared to control dogs (744 pmol/L; 531-2710 pmol/L) (p=0.0339). [NT-proBNP] was associated with peak TR gradient (R2=0.7851, p=0.0001). Median [NT-proANP] did not differ between dogs with PH (1747 fmol/L; 894-2884 fmol/L) and control dogs (1209 fmol/L; 976-1389 fmol/L (p=0.058)). [NT-proANP] was not associated with peak TR gradient (R2=0.2780, p=0.0781). Median [cTnI] did not differ between dogs with PH (0.2850 ng/mL; 0.19-1.13 ng/mL) and control dogs (0.2 ng/mL; 0.19-0.82 ng/mL, p=0.3051). Median [TnI] was not associated with peak TR gradient (R2=0.024, p=0.6307). Conclusions: [NT-proBNP] concentration is significantly higher in dogs with pre-capillary PH when compared to dogs with respiratory disease without PH, and [NT-proBNP] may be useful to predict the severity of estimated PH. Elevations in [NT-proBNP] due to pre-capillary PH may complicate the interpretation of [NT-proBNP] elevations in patients presenting with cardiorespiratory abnormalities. [NT-proANP] and [cTnI] were not elevated in dogs with pre-capillary PH.Digital Object Identifier http://dx.doi.org/10.1016/j.jvc.2011.04.003
机译：目的：将[NT-ProBNP]，[NT-ProAnP]，[NT-ProAnP]和[CTNI]与呼吸道疾病（pH）和毛细血管pH的狗进行呼吸道疾病，并评估[NT-Probnp]的准确性，[nt-proanp]，[ctni]预测多普勒衍生的峰三尖瓣渐变（tr）梯度。动物：20只狗。 8对照犬，呼吸道疾病没有pH和12具有毛细管pH值。方法：在2组之间比较[NT-ProPNP]，[NT-ProAnp]和[CTNI]，并且使用简单的线性回归分析来预测来自各种血液生物标志物的峰TR梯度。结果：与对照犬（744pmol / L; 531-2710 pmol / L）相比，犬（2011pmol / L，274-7713 pmol / L）中位数[nt-probnp]较高（2011pmol / l，274-7713 pmol / l）（ p = 0.0339）。 [NT-probNP]与峰TR梯度（ R r> 2 = 0.7851相关， p = 0.0001）。中位数[nt-proanp]没有pH的狗（1747 fmol / l; 894-2884 fmol / l）和对照犬（1209 fmol / l; 976-1389 fmol / l（ p 之间= 0.058））。 [NT-ProAnp]与峰Tr梯度（ R 2 = 0.2780， p = 0.0781）无关。中位数[CTNI]在pH（0.2850ng / ml; 0.19-1.13ng / ml）和对照犬（0.2ng / ml; 0.19-0.82ng / ml， p = 0.3051之间的狗之间没有差异）。中值[TNI]与峰TR梯度无关（ R 2 = 0.024， p = 0.6307）。结论：与没有pH的呼吸道疾病的狗相比，毛细血管pH的狗浓度显着高，并且[nt-probnp]可用于预测估计pH的严重程度。由于毛细血管前pH，[NT-probnp]的升高可能使患者患有心肺异常的患者的[NT-PROPNP]升高的解释。 [NT-ProAnp]和[CTNI]未在毛细血管ph.Digital对象标识符中升高到毛发毛细血管上升高）http://dx.doi.org/10.1016/j.jvc.2011.04.003

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