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首页> 外文期刊>Journal of veterinary cardiology >Plasma N-terminal pro-brain natriuretic peptide concentrations before and after pericardiocentesis in dogs with cardiac tamponade secondary to spontaneous pericardial effusion
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Plasma N-terminal pro-brain natriuretic peptide concentrations before and after pericardiocentesis in dogs with cardiac tamponade secondary to spontaneous pericardial effusion

机译：血浆N-末端的脑卒中前后血液穿刺前后血液穿刺前后的血管内穿孔前后，具有次要的心脏透明棉条患者

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ObjectiveTo determine if concentrations of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) are increased in dogs with cardiac tamponade and if there is a significant increase in plasma NT-proBNP after pericardiocentesis.AnimalsTen client-owned dogs with spontaneous cardiac tamponade.MethodsProspective clinical study. Cardiac tamponade was suspected from physical examination and confirmed with echocardiography. Blood was collected and plasma NT-proBNP concentrations were measured before and 30–60?min following pericardiocentesis and resolution of cardiac tamponade. Within-subject changes in plasma NT-proBNP were compared by the Wilcoxon signed-rank test.ResultsThe plasma NT-proBNP concentrations measured within the reference interval in seven of 10 dogs before pericardiocentesis and in six of 10 dogs following pericardiocentesis. Following pericardiocentesis, there was a statistically significant increase in median NT-proBNP concentration (733?pmol/L, range 250–3,297) compared with the values measured before (643?pmol/L, range 250–3,210, P?=?0.004). The NT-proBNP concentration increased in 90% of the dogs following pericardiocentesis.ConclusionsAn upper reference limit of 900?pmol/L for plasma NT-proBNP is insensitive for the diagnosis of pericardial effusion and cardiac tamponade in dogs. Plasma NT-proBNP concentration commonly increases following pericardiocentesis, perhaps related to improved ventricular filling and stretch.
机译：atfectoriveto确定血浆N-末端的血液血液培养基的浓度是否增加，患有心脏铺位的狗的血液含量，如果血浆熵术后血浆NT-probnp的显着增加。自发性心脏局部局部局部的血管。方法普遍存在临床研究。心脏铺位局部受到体检和超声心动图证实。收集血液，并在心包复位后测量血浆NT-PROPNP浓度，30-60Ω分钟和心脏填塞后的分辨率。通过紫罗逊签名秩检测比较了血浆NT-probnp的对象内。血浆NT-PROPNP浓度在先端穿刺前7名10只狗中的参考间隔中测量的血浆NT-PROPNP浓度在10只犬内，10只犬内穿孔术后的六只犬。与之前测量的值相比，心包血穿刺术后，中位数NT-PROPNP浓度（733μmol/ L，范围250-3,297）存在统计学上显着的增加（643？PMOL / L，范围250-3,210，p？= 0.004 ）。心包过术后90％的狗的NT-proPNP浓度增加了900℃的上参考限值，对于血浆NT-probnp对血浆NT-probNP的不敏感，对狗的心包积液和心脏棉签的诊断不敏感。血浆NT-proPNP浓度通常在心包中穿孔后增加，可能与改善的心室填充和伸展相关。

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