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首页> 外文期刊>Journal of toxicology and environmental health, Part A >Effects of Gestational Exposure to Decabromodiphenyl Ether on Reproductive Parameters, Thyroid Hormone Levels, and Neuronal Development in Sprague-Dawley Rats Offspring
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Effects of Gestational Exposure to Decabromodiphenyl Ether on Reproductive Parameters, Thyroid Hormone Levels, and Neuronal Development in Sprague-Dawley Rats Offspring

机译：妊娠期暴露在Sprague-Dawley大鼠后代生殖参数，甲状腺激素水平，甲状腺激素水平和神经元发育中的影响

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摘要

Polybrominated diphenyl ethers (PBDE) are a class of bromi-nated flame retardants that are recognized as global environmental contaminants with potential adverse effects on human health. This study examined the effects of prenatal exposure to PBDE on reproductive organs, neuronal development, and levels of thyroid hormones. Pregnant rats were exposed to the vehicle or decabromodiphenyl ether (BDE) (BDE-209; 5, 40, or 320 mg/kg body weight/d) during gestation days (GD) 6-18. There was a significant decrease in body weight gain in F1 male offspring exposed to high-dose (320 mg/kg) BDE-209. Significant increases in thyroid weight and a decrease in adrenal weight were observed in high-dose BDE-209. Thyroxine (T4) concentrations were significantly lower in Fl female offspring exposed to BDE-209 at postnatal day (PND) 42. This reduction was more pronounced in the group exposed to higher doses. A low dose (5 mg/kg) of BDE-209 significantly reduced serum estradiol concentration in female offspring but did not affect testosterone levels in males. There was no significant effect on hippocampal neurogenesis in BDE-209 treatment groups. In conclusion, there was no apparent association between thyroid hormone concentrations and low birth weight in Fl rats after gestational exposure to BDE-209.
机译：多溴二苯醚（PBDE）是一类溴荷阻燃剂，被认为是全球环境污染物，具有对人体健康的潜在不利影响。本研究检测了产前暴露对PBDE对生殖器官，神经元发育和甲状腺激素水平的影响。在妊娠日（GD）6-18期间，将孕术大鼠暴露于载体或癸溴二苯醚（BDE-209; 5,40，或320mg / kg体重/ d）。 F1阳性后代的体重增加有显着降低，暴露于高剂量（320mg / kg）BDE-209。在高剂量BDE-209中观察到甲状腺重量的显着增加和肾上腺重量的降低。在后期（PND）42下暴露于BDE-209的FL雌性后代的甲状腺素（T4）浓度显着降低。在暴露于更高剂量的组中，这种还原更加明显。低剂量（5mg / kg）的BDE-209显着降低了雌性后代的血清雌二醇浓度，但不影响雄性睾酮水平。对BDE-209治疗组的海马神经发生没有显着影响。总之，在妊娠期暴露于BDE-209之后，甲状腺激素浓度与甲状腺大鼠的低出生体重不明显关联。

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