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首页> 外文期刊>Journal of toxicology and environmental health, Part B. Critical reviews >COMPUTATIONAL TOXICOLOGY AS IMPLEMENTED BY THE U.S. EPA: PROVIDING HIGH THROUGHPUT DECISION SUPPORT TOOLS FOR SCREENING AND ASSESSING CHEMICAL EXPOSURE, HAZARD AND RISK
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COMPUTATIONAL TOXICOLOGY AS IMPLEMENTED BY THE U.S. EPA: PROVIDING HIGH THROUGHPUT DECISION SUPPORT TOOLS FOR SCREENING AND ASSESSING CHEMICAL EXPOSURE, HAZARD AND RISK

机译：由美国EPA实施的计算毒理学：为筛选和评估化学曝光，危险和风险提供高吞吐量决策支持工具

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Computational toxicology is the application of mathematical and computer models to help assess chemical hazards and risks to human health and the environment. Supported by advances in informatics, high-throughput screening (HTS) technologies, and systems biology, the U.S. Environmental Protection Agency EPA is developing robust and flexible computational tools that can be applied to the thousands of chemicals in commerce, and contaminant mixtures found in air, water, and hazardous-waste sites. The Office of Research and Development (ORD) Computational Toxicology Research Program (CTRP) is composed of three main elements. The largest component is the National Center for Computational Toxicology (NCCT), which was established in 2005 to coordinate research on chemical screening and prioritization, informatics, and systems modeling. The second element consists of related activities in the National Health and Environmental Effects Research Laboratory (NHEERL) and the National Exposure Research Laboratory (NERL). The third and final component consists of academic centers working on various aspects of computational toxicology and funded by the U.S. EPA Science to Achieve Results (STAR) program. Together these elements form the key components in the implementation of both the initial strategy, A Framework for a Computational Toxicology Research Program (U.S. EPA, 2003), and the newly released The U.S. Environmental Protection Agency's Strategic Plan for Evaluating the Toxicity of Chemicals (U.S. EPA, 2009a). Key intramural projects of the CTRP include digitizing legacy toxicity testing information toxicity reference database (ToxRefDB), predicting toxicity (ToxCast) and exposure (ExpoCast), and creating virtual liver (v-Liver) and virtual embryo (v-Embryo) systems models. U.S. EPA-funded STAR centers are also providing bioinformatics, computational toxicology data and models, and developmental toxicity data and models. The models and underlying data are being made public...
机译：计算毒理学是数学和计算机模型的应用，以帮助评估对人体健康和环境的化学危害和风险。美国环境保护署EPA的信息学，高吞吐量筛查（HTS）技术和系统生物学的进步支持，这是开发稳健且灵活的计算工具，可应用于商业的数千种化学品，以及空中发现的污染物混合物，水和危险场地。研发办公室（ORD）计算毒理学研究计划（CTRP）由三个主要元素组成。最大的组成部分是国家计算毒理学中心（NCCT），成立于2005年，以协调化学筛选和优先级，信息学和系统建模研究。第二个要素由国家健康和环境影响研究实验室（NHEERL）和国家曝光研究实验室（NERL）的相关活动组成。第三个和最终组成部分由致力于计算毒理学的各个方面的学术中心组成，并由美国EPA科学资助实现结果（明星）计划。这些要素在一起形成了实施初始策略的关键组成部分，这是一个计算毒理学研究计划（美国EPA，2003）的框架，以及新发布的美国环境保护局评估化学品毒性的战略计划（美国EPA，2009A）。 CTRP的主要历史项目包括数字化遗留毒性测试信息毒性参考数据库（TOXREFDB），预测毒性（TOXCAST）和曝光（Expocast），以及创建虚拟肝脏（V-Liver）和虚拟胚胎（V-EMIRO）系统模型。美国EPA资助的星中心还提供生物信息学，计算毒理学数据和模型以及发展毒性数据和模型。模型和基础数据正在公开......

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