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首页> 外文期刊>Journal of Veterinary Research >Changes in blood lymphocyte subpopulations and expression of MHC-II molecules in wild mares before and after parturition
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Changes in blood lymphocyte subpopulations and expression of MHC-II molecules in wild mares before and after parturition

机译：血浆血液淋巴细胞群的变化和野生母乳中的MHC-II分子表达

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Introduction: Pregnancy is a physiological state in which the immune system undergoes certain changes. On the one hand, by depleting cell defence mechanisms, it favours development and maintenance of the pregnancy. At the same time cells of the immune system ensure resistance to many risk factors, including infectious agents. Material and Methods: The study was carried out on 24 Polish Konik breed mares which were divided into two equal groups. The first group (group I) included mares living in the reserve. The second group (group II) comprised mares maintained under conventional conditions in the stables. The blood samples were collected for the first time in the perinatal period, i.e. 2 weeks before parturition (trial 0), then within the first 24 h after delivery, and then on 7(th) and 21(st) day after foaling. Flow cytometric analysis of lymphocyte expressing TCD4+, TCD8+, CD2+, and MHC class II antigens was performed. Results: Before the delivery, in group I there was a significantly higher CD4:CD8 ratio compared to group II (P <= 0.05). Similarly, significantly increased CD4:CD8 ratio in group I was noted within 24 h after parturition (P <= 0.001) and it was also observed on 7(th) day (P <= 0.03) and 21(st) day after foaling (P <= 0.02). In the first 24 h after parturition, a significant decline of lymphocytes CD8+ (P <= 0.02) was noted. No significant differences in terms of lymphocytes CD2+ and CD3+ were observed. Expression of MHC-II molecules before and after the parturition was higher in group I compared to group II; however, the difference between the groups was not significant. Conclusion: The results obtained indicate that mares living in the reserve display higher activity of cell defence mechanisms.
机译：简介：妊娠是一种生理状态，其中免疫系统经历某些变化。一方面，通过耗尽细胞防御机制，它有利于开发和维护怀孕。同时，免疫系统的细胞确保对许多危险因素的抵抗力，包括传染病。材料和方法：该研究在24种波兰konik繁殖母马中进行，分为两个相等的群体。第一个组（第I组）包括生活在储备金的母舰。第二组（II组）包含在马厩中常规条件维持的母马。在围产期中首次收集血液样品，即分娩前2周（试验0），然后在发泡后的第7（Th）和21（ST）的第7天（Th）和21天（ST）。表达TCD4 +，TCD8 +，CD2 +和MHC II类抗原的淋巴细胞流式细胞术分析。结果：在递送之前，在组中，与II组相比，CD4：CD8比率显着更高（P <= 0.05）。同样，在分娩后24小时内注意到，在24小时内（P <= 0.001）在24小时内发现CD4：在发泡后的7（P <= 0.03）和21（ST）日（ p <= 0.02）。在分娩后的前24小时，注意到淋巴细胞CD8 +（P <= 0.02）的显着下降。观察到淋巴细胞CD2 +和CD3 +无显着差异。与II组相比，分娩前后的MHC-II分子的表达较高;然而，组之间的差异并不重要。结论：得到的结果表明，生活在储备中的母舰显示细胞防御机制的更高活动。

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