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Early detection of active glomerular lesions in dogs and cats using podocin

机译:利用豆荚早期检测狗和猫的活性肾小球病变

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摘要

In veterinary medicine, sensitive and specific markers of the early stages of renal failure still remain to be established. Podocytes could be a promising diagnostic tool in veterinary nephrology, especially in the differentiation of active pathological disease and glomerulopathies. Podocin is one of the robust proteins exploitable in detection of podocyturia. This article presents podocyte detection in urine for diagnostic purposes in veterinary medicine using a variety of methods. We describe the advantages and disadvantages of the immunohistochemical technique currently used, and of scanning microscopy, chromatography, and immunostaining. The identification of podocin-positive cells is a promising diagnostic tool in the detection of the early stages of glomerular basement membrane damage. The detection of renal failure prior to the occurrence of azotaemia is of high clinical importance from the clinical and scientific points of view.
机译:在兽医药物中,仍然仍然建立肾功能衰竭的早期阶段的敏感和特异性标记。 足细胞可能是兽医肾脏的有希望的诊断工具,尤其是在有源病理疾病和肾小球术的分化中。 Podocin是在检测Podocyturia检测的强大蛋白质之一。 本文介绍了尿液中的尿液中使用多种方法诊断目的。 我们描述了目前使用的免疫组化技术和扫描显微镜,色谱和免疫染色的优点和缺点。 在检测肾小球基底膜损伤的早期阶段,靶阳性细胞的鉴定是有前途的诊断工具。 在抑郁症发生之前检测肾功能衰竭是从临床和科学观点的高临床重要性。

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