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Effect of TNF-alpha concentration on selected clinical parameters of swine after burns

机译：TNF-α浓度对烧伤后猪选定临床参数的影响

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Introduction: The study aimed to observe TNF-alpha serum concentration as well as changes in respiration rate, body temperature, and pulse rate in burn victims during 84 h post burn. Material and Methods: A total of 30 healthy pigs were divided into two groups: A, the test group and N, the control group. The experimental group suffered burns to 30% of the body surface, and after infliction of the burns both groups were closely monitored. Results: The biggest increase in TNF-alpha serum concentration in the test subjects occurred around the 6th h of the study, and the second biggest increase took place between 12th and 36th h. In the 36th h, TNF-alpha was 2.5 times more concentrated in serum in the test group than in the control group. In the test group, the biggest increase in respiration rate occurred up to the 6th h post burn, on average up to 29/min. In the 12th h post burn, the mean pulse rate in the test group was 133/min and dropped to the lowest value in the 72 nd h of the experiment. A gradual increase in body temperature up to 41.72 degrees C was observed up to the 30th h post burn and decreased to a significant value of 40.74 degrees C by the 84th h of the study. Conclusion: In a period of a pronounced rise in TNF-alpha serum concentration, this parameter, pulse rate, and respiration rate are highly correlated and are also influenced by multiple inflammation forming factors.
机译：介绍：该研究旨在观察TNF-α血清浓度以及烧伤后烧伤受害者的呼吸速率，体温和脉搏率的变化。材料和方法：将30只健康猪分为两组：A，试验组和N，对照组。实验组患有体面的30％，并且在抑制烧伤后，两组被严格监测。结果：在研究第6岁左右发生测试对象中TNF-α血清浓度的最大增加，第12和第36段之间的第二大增幅发生。在第36阶段，TNF-α在试验组中血清中浓缩的2.5倍，而不是对照组。在试验组中，呼吸率最大的增加发生在烧伤后6小时，平均最多29 / min。在第12次燃烧后，试验组的平均脉冲率为133 / min，并降至实验72 ND H中的最低值。在第30次燃烧后观察到最高可达41.72℃的体温逐渐增加，并在研究的第84℃下降到40.74摄氏度的显着值。结论：在TNF-α血清浓度的一段时间内，该参数，脉搏率和呼吸速率高度相关，并且也受到多种炎症形成因素的影响。

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