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首页> 外文期刊>Journal of Zoo and Wildlife Medicine >INTRAVENOUS VATINOXAN IN MARKHORS (CAPRA FALCONERI HEPTNERI) IMMOBILIZED WITH INTRAMUSCULAR MEDETOMIDINE AND KETAMINE-A PRELIMINARY DOSESCREENING STUDY
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INTRAVENOUS VATINOXAN IN MARKHORS (CAPRA FALCONERI HEPTNERI) IMMOBILIZED WITH INTRAMUSCULAR MEDETOMIDINE AND KETAMINE-A PRELIMINARY DOSESCREENING STUDY

机译：Markhors（Capra Falconeri Heptneri）的静脉内Vatinoxan固定在肌肉内胚胎和氯胺酮-A初步用量筛选研究

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摘要

Medetomidine is an alpha-2 adrenoceptor agonist commonly combined with ketamine for immobilization of nondomestic mammals. However, it may cause some remarkable adverse effects such as bradycardia, hypertension, and hypoxemia. Vatinoxan (previously called MK-467 and L-659,066) is an alpha-2 adrenoceptor antagonist that affects mostly the peripheral receptors due to its minimal ability to cross the blood-brain barrier. Therefore it alleviates the peripheral cardiovascular and pulmonary effects of medetomidine while sedation is maintained. In this study, the hypothesis was that vatinoxan would dose-dependently alleviate medetomidineinduced bradycardia, hypertension, and hypoxemia when administered intravenously (IV) after medetomidine and ketamine were administered intramuscularly (IM) to markhors (Capra falconeri heptnen), without impairing the immobilization. Various doses of vatinoxan were studied. In this prospective, randomized, assessor-blinded, clinical crossover study, eight markhors were immobilized two times (16 paired immobilizations altogether) with medetomidine (80 mu g/kg) and ketaminc (1.5 mg/kg), according to the estimated weight, IM in the same dart. Approximately 19 min later, vatinoxan (117-297 mu g/kg) or saline placebo was injected IV. Atipamezole was used as a reversal agent. Pulse and respiratory rates, indirect blood pressures, arterial oxygen saturation, and body temperature were measured and blood samples collected. In general, vatinoxan alleviated the hypertension induced by medetomidine without affecting the quality of immobilization. The dose of vatinoxan correlated significantly with the reduction in arterial blood pressure. Vatinoxan showed potential to enhance cardiovascular function in captive nondomestic small ruminants immobilized with medetomidine-ketamine.
机译：Mebetomidine是α-2肾上腺素受精剂激动剂，通常与氯胺酮相结合，以固定非组分哺乳动物。然而，它可能导致一些显着的不良反应，例如Br​​adycardia，高血压和低氧血症。 Vatinoxan（先前称为MK-467和L-659,066）是一种α-2肾上腺素受体拮抗剂，由于其血脑屏障的最小能力，主要影响外围受体。因此，它减轻了沉积物的外周心血管和脑膜血管的肺部效应。在这项研究中，假设是，当静脉内（IM）术中（IM）给Markhors（Capra Falconeri Heptnen）后，Vatinoxan将剂量依赖性缓解杂皮物（IV）给药时静脉内（IV）给药研究了各种剂量的Vatinoxan。在这种前瞻性，随机，评估综合症，临床交叉研究中，将八个Markors固定在估计的重量，我在同一块飞镖。大约19分钟后，vatinoxan（117-297 mu g / kg）或盐安慰剂注射IV。 Atipamezole用作逆转剂。测量脉冲和呼吸速率，间接血压，动脉氧饱和度和体温，并收集血液样品。通常，Vatinoxan减轻了Medetomidine诱导的高血压，而不会影响固定质量。 Vatinoxan的剂量随着动脉血压的降低而显着相关。 vatinoxan显示潜力，以增强俘虏Nondomestic小型反刍动物的心血管功能，其固定在用Medetomidine-氯胺酮固定。

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