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首页> 外文期刊>Journal of women’s health >The Timing Hypothesis: Hormone Therapy for Treating Symptomatic Women During Menopause and Its Relationship to Cardiovascular Disease
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The Timing Hypothesis: Hormone Therapy for Treating Symptomatic Women During Menopause and Its Relationship to Cardiovascular Disease

机译：定时假设：荷尔蒙治疗症状妇女在更年期期间治疗及其与心血管疾病的关系

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摘要

The risks and benefits of menopausal hormonal therapy (HT) have been evaluated extensively over the past three decades. While the efficacy of HT for management of menopausal symptoms, including vasomotor symptoms and vaginal dryness is well established, its relationship to cardiovascular outcomes is complex. The timing hypothesis, which posits that the cardiovascular effects of HT depend on the timing of initiation of HT in relation to menopause, has helped shape our understanding of the cardiovascular outcomes related to HT. Based on results from female monkey studies, the timing hypothesis provides a framework to explain discrepancies in results between multiple observation studies and the Women's Health Initiative (WHI) hormone therapy trials. The WHI trials closed early in 2002 in part because of increased cardiovascular events seen in women on treatment. Subanalysis of the WHI results by age group, and more recent randomized control studies, including the Kronos Early Estrogen and Prevention Study (KEEPS) and Early Versus Late Intervention Trial (ELITE), demonstrate that the risk of adverse cardiovascular events for HT are low for women <60 years of age or within 10 year from menopause. Although current data does not support using HT for primary prevention of cardiovascular disease, it does suggest that HT can be safely used to treat symptoms in appropriately selected women close to menopause.
机译：在过去的三十年里，预期荷尔蒙治疗（HT）的风险和益处已被广泛评估。虽然HT对更年期症状的治疗，包括血管传离症状和阴道干燥的疗效得到了很好的成立，但其与心血管结果的关系是复杂的。定时假设，其定时，它的心血管效应依赖于与更年期相关的HT开始的时间，帮助塑造了对与HT相关的心血管结果的理解。基于女性猴子研究的结果，时序假设提供了一种框架，以解释在多个观察研究和女性健康倡议（WHI）激素治疗试验之间的结果之间的差异。 WHI试验在2002年初闭幕，部分原因是妇女治疗中的心血管事件增加。通过年龄组的WHI结果细胞分析，以及最近的随机对照研究，包括Kronos早期雌激素和预防研究（保持）和早期干预试验（Elite），表明HT的不良心血管事件的风险很低妇女<60岁或10年内从更年期内。 Although current data does not support using HT for primary prevention of cardiovascular disease, it does suggest that HT can be safely used to treat symptoms in appropriately selected women close to menopause.

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